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Details for Product No. ABIN318927

Plexin Domain Containing 1 (PLXDC1) antibody

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Antigen
Synonyms TEM3, TEM7, Arl12, Tem7, 2410003I07Rik, AI848450, PLXDC1
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN318927
Quantity 0.1 mg
Price
500.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen A 16 amino acid peptide from near the centre of Human TEM7.
Isotype IgG
Specificity This antibody recognises Human Tumour endothelial marker 7 (TEM7), a 55.8 kDa protein belonging to the plexin family.
Purification Affinity Chromatography
Alternative Name PLXDC1 / TEM7
Background TEM7 is strongly expressed in endothelial cells from colorectal cancer and from primary cancers of the lung, liver, brain, breast and pancreas. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. Studies have indicated the existence of least four isoforms of TEM7 which include membrane bound, secreted and intracellular forms. TEM7 is not detectable in endothelial cells from normal tissues.
Alternate names: Plexin domain-containing protein 1, TEM3, Tumor endothelial marker 3, Tumor endothelial marker 7
Gene ID 57125
NCBI Accession NP_065138.2
UniProt Q8IUK5
Application Notes Western Blot: 0.5 - 1.0g/ml, detects a band of approximately 56kDa in rat liver tissuelysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Cross, Lindsey, Fantes et al.: "The structure of a subterminal repeated sequence present on many human chromosomes." in: Nucleic acids research, Vol. 18, Issue 22, pp. 6649-57, 1991 (PubMed).

St Croix, Rago, Velculescu et al.: "Genes expressed in human tumor endothelium." in: Science (New York, N.Y.), Vol. 289, Issue 5482, pp. 1197-202, 2000 (PubMed).

Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Fuchs, Mahlum, Halder et al.: "High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma." in: Gene, Vol. 399, Issue 2, pp. 137-43, 2007 (PubMed).

Alternatives for antigen "Plexin Domain Containing 1 (PLXDC1)", type "Antibodies"
Hosts (45), (11)
Reactivities (53), (22), (21), (1), (1)
Applications (49), (32), (25), (18), (5), (2), (2), (1), (1), (1)
Epitopes (14), (5), (4), (3), (2), (2), (2), (2), (1), (1)
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