CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (C-Term), (AA 191-209) antibody

Details for Product No. ABIN318973
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
Clarp1, cflar, CFLAR, FLIP, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, 2310024N18Rik, A430105C05Rik, Cash, ENSMUSG00000072980, Flip, Gm984 ... show more
Clarp1, cflar, CFLAR, FLIP, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, 2310024N18Rik, A430105C05Rik, Cash, ENSMUSG00000072980, Flip, Gm9845, c-Flip show less
Epitope
C-Term, AA 191-209
(46), (21), (11), (11), (9), (6), (6), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(176), (76), (54), (26), (26), (26), (12), (3)
Host
Rabbit
(153), (44), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(160), (66), (40), (32), (30), (28), (20), (14), (11), (9), (7), (5), (3), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN318973
423.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A peptide corresponding to aa191 - 209 at the C-terminus of human FLIP delta/FLIPs form.
Isotype IgG
Specificity This antibody recognises the apoptosis related protein designated FLIP (FLICE inhibitory protein).
Purification Purified
Alternative Name CFLAR / Casper / I-FLICE
Background FLIP interacts with the adaptor protein FADD, and with Caspase-8 (FLICE) and Caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1. FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. AHP1591 recognizes human and murine delta and gamma variants but not the alpha or beta, variants. FLIP is widely expressed in human tissues and a diverse range of cell lines.Synonyms: CASH, CASP8 and FADD-like apoptosis regulator, CASP8AP1, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, c-FLIP
Gene ID 8837
NCBI Accession NP_001120655
UniProt O15519
Application Notes Immunohistochemistry on frozen sections: 2g/mL. Western Blot: 1: 1000, detects bands of approximately 35 kDa and 25 kDa in Jurkat celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)
Preservative Sodium azide
Precaution of Use This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (C-Term), (AA 191-209) antibody anti-CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (C-Term), (AA 191-209) antibody
anti-CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (C-Term), (AA 191-209) antibody (2) anti-CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (C-Term), (AA 191-209) antibody (Image 2)
Background publications Thome, Schneider, Hofmann et al.: "Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors." in: Nature, Vol. 386, Issue 6624, pp. 517-21, 1997 (PubMed).

Shu, Halpin, Goeddel: "Casper is a FADD- and caspase-related inducer of apoptosis." in: Immunity, Vol. 6, Issue 6, pp. 751-63, 1997 (PubMed).

Hu, Vincenz, Ni et al.: "I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 28, pp. 17255-7, 1997 (PubMed).

Irmler, Thome, Hahne et al.: "Inhibition of death receptor signals by cellular FLIP." in: Nature, Vol. 388, Issue 6638, pp. 190-5, 1997 (PubMed).

Validation Images
Did you look for something else?
back to top