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Caspase 12 (CASP12) (AA 100-116) antibody

Details for Product No. ABIN319042
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Antigen
Synonyms Caspase-12
Epitope
AA 100-116
(12), (10), (8), (8), (8), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(91), (90), (67)
Host
Rabbit
(117), (9), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(106), (55), (47), (37), (20), (14), (11), (8), (5), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN319042
286.00 $
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Immunogen Synthetic peptide corresponding to amino acids 100-116 of murine caspase 12.
Isotype IgG
Specificity This antibody recognises an epitope within the internal region of murine caspase 12. Caspase 12 is a member of the interleukin-1 Beta converting enzyme (ICE) subfamily of caspases. Caspase 12 is ubiquitously expressed in murine tissue and is localised to the endoplasmic reticulum.
Purification Purified
Alternative Name Caspase-12
Background The Caspase family of cysteine proteases play a key role in apoptosis. Three distinct signaling pathways lead to apoptosis. The death receptor and mitochondrion pathways are the main ways in which the key apoptotic proteases Caspase 8 and Caspase 9, respectively, are involved. Caspase 12 is localised to the ER and is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase 12 is believed to mediate apoptosis in response to endoplasmic reticulum stress. Caspase 12 is colocalized to the ER with several proteins that are involved in Alzheimers disease including g-secretase presenilin and b-amyloid precursor protein (APP).
Alternate names: CASP-12, CASP12, Inactive caspase-12
Gene ID 100506742
NCBI Accession NP_001177945.1
UniProt Q6UXS9
Research Area Apoptosis/Necrosis
Application Notes Western Blot: 0.5g/ml - 1g/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Phosphate buffered saline containing 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Van de Craen, Vandenabeele, Declercq et al.: "Characterization of seven murine caspase family members." in: FEBS letters, Vol. 403, Issue 1, pp. 61-9, 1997 (PubMed).

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