NMDA Receptor 1 (Splice Variant N1) antibody

Details for Product No. ABIN319152
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Antigen
Synonyms CG2902, DMNMDAR1, DNMDAR-I, DNmdar, DmelNmdar1, Dmel\\CG2902, DrNR1, NMDA, NMDA R1, NMDAR1, NMdar1, NR1, NRI, Nmdar, dNR1, dnmdar-I, nmr
Epitope
Splice Variant N1
(3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus), Xenopus laevis
(29), (23), (21), (5), (4), (1), (1)
Host
Rabbit
(31), (3), (2)
Clonality
Polyclonal
Application
Western Blotting (WB)
(28), (9), (8), (5), (4), (3), (2), (2)
Pubmed 2 references available
Quantity 25 µg
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Catalog No. ABIN319152
709.50 $
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Immunogen Synthetic peptide from rat NMDA receptor NR1 subunit, containing the N1 splice variant insert.
Isotype IgG
Specificity This antibody specifically recognises the 120kDa NR1 subunit of the NMDA (N-methyl-D- aspartate) Receptor, containing the N1 splice variant insert. This antibody does not recognize the NR1 subunit, where the N1 splice variant insert is absent.
Purification Affinity chromatography
Background Receptors for NMDA (NMDAR) belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+ permeability. The NR1 subunit has eight splice variants, arising from either the deletion or insertion of three exon cassettes within the C-terminal (C1, C2) and N-terminal (N1) NR1 domains. These splice variants differ in both their expression and pharmacological properties.
Alternate names: GRIN1, Glutamate [NMDA] receptor subunit zeta-1, NMDAR1
Gene ID 24408
NCBI Accession NP_058706
UniProt P35439
Research Area Neurotransmitters, Receptors
Application Notes Western Blot: 1: 1000, detects a band of approximately 120kDa in HEK293 cell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 50 µL phosphate buffered saline. For long term storage the addition of 0.09% sodium azide is recommended.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C.
Expiry Date 12 months
Background publications Ishii, Moriyoshi, Sugihara et al.: "Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits." in: The Journal of biological chemistry, Vol. 268, Issue 4, pp. 2836-43, 1993 (PubMed).

Ehlers, Fung, OBrien et al.: "Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 2, pp. 720-30, 1998 (PubMed).

Validation Images
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