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Aurora A antibody (Aurora Kinase A) (pThr288)

Details for Product anti-AURKA Antibody No. ABIN319281, Supplier: Log in to see
Antigen
  • 87A7-9/2
  • Aur-A
  • AurA
  • CG3068
  • Dmel\\CG3068
  • aur-A
  • aurA
  • ck10
  • ck[10]
  • l(3)87Ac
  • l(3)ck10
  • Aurora-A
  • Eg2
  • aik
  • ark1
  • aur-a
  • aura
  • aurora2
  • btak
  • pEg2
  • stk15
  • stk6
  • stk7
  • wu:fb37c10
  • wu:fc02c02
  • zgc:100912
  • AURKA
  • aurka
  • AIK
  • ARK1
  • AURA
  • AURORA2
  • BTAK
  • PPP1R47
  • STK15
  • STK6
  • STK7
  • AIRK1
  • AU019385
  • AW539821
  • Ark1
  • Ayk1
  • IAK
  • IAK1
  • Stk6
  • ARK-1
  • aurka-a
Alternatives
anti-Human Aurora A antibody for Immunofluorescence
Epitope
pThr288
46
40
30
15
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
217
74
49
14
8
8
3
2
1
1
1
1
Host
Rabbit
168
56
19
Clonality
Polyclonal
Conjugate
This Aurora A antibody is un-conjugated
10
6
6
5
5
5
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
186
86
77
50
33
28
15
15
12
5
4
2
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Aurora A around the phosphorylation site of Threonine 288 (R-T-TP-L-M).
Specificity Aurora A (phospho-Thr288) Antibody AP08036PU detects endogenous levels of Aurora A only when phosphorylated at Threonine 288.
Purification Immunoaffinity Chromatography: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Aurora Kinase A (AURKA Antibody Abstract)
Background Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Synonyms: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor-amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6
Gene ID 6790
NCBI Accession NP_003591
UniProt O14965
Pathways Cell Division Cycle
Application Notes Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-Aurora A antibody (Aurora Kinase A) (pThr288) (ABIN319281) anti-Aurora Kinase A (AURKA) (pThr288) antibody
Background publications Hauf, Cole, LaTerra et al.: "The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint." in: The Journal of cell biology, Vol. 161, Issue 2, pp. 281-94, 2003 (PubMed).

Walter, Seghezzi, Korver et al.: "The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation." in: Oncogene, Vol. 19, Issue 42, pp. 4906-16, 2000 (PubMed).

Ellis: "The war of the sex chromosomes." in: Nature genetics, Vol. 20, Issue 1, pp. 9-10, 1998 (PubMed).

Bischoff, Anderson, Zhu et al.: "A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers." in: The EMBO journal, Vol. 17, Issue 11, pp. 3052-65, 1998 (PubMed).