KIT antibody (Mast/stem Cell Growth Factor Receptor) (pTyr936)

Details for Product anti-KIT Antibody No. ABIN319287, Supplier: Log in to see
Antigen
  • C-Kit
  • CD117
  • PBT
  • SCFR
  • Bs
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • c-kit
  • MGF
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • kit oncogene
  • KIT
  • Kit
Alternatives
anti-Human KIT antibody for Immunofluorescence
Epitope
pTyr936
99
83
67
63
47
38
35
34
33
33
27
20
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2
1
1
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1
1
1
1
1
1
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1
1
1
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Reactivity
Human
1382
595
163
48
42
37
29
19
15
6
6
5
5
4
3
2
1
1
Host
Rabbit
1090
353
277
16
2
2
Clonality
Polyclonal
Conjugate
This KIT antibody is un-conjugated
150
132
128
100
86
74
25
21
15
13
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10
9
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2
1
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
705
655
496
360
275
181
123
105
85
81
39
14
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12
8
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4
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3
2
2
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1
Options
Supplier
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Supplier Product No.
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human c- kit around the phosphorylation site of Tyrosine 936 (H-I-YP-S-N).
Specificity C-kit (phospho-Tyr936) Antibody AP08039PU detects endogenous levels of c-kit only when phosphorylated at Tyrosine 936.
Purification Immunoaffinity Chromatography.
Alternative Name CD117 / C-Kit (KIT Antibody Abstract)
Background C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID 3815
NCBI Accession NP_000213
UniProt P10721
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors, Receptors, Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr936) antibody (ABIN319287) anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr936) antibody
Background publications Blume-Jensen, Jiang, Hyman, Lee, OGorman, Hunter: "Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility." in: Nature genetics, Vol. 24, Issue 2, pp. 157-62, 2000 (PubMed).

Lowe: "Colipase stabilizes the lid domain of pancreatic triglyceride lipase." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 9-12, 1997 (PubMed).

Martin, Suggs, Langley, Lu, Ting, Okino, Morris, McNiece, Jacobsen, Mendiaz: "Primary structure and functional expression of rat and human stem cell factor DNAs." in: Cell, Vol. 63, Issue 1, pp. 203-11, 1990 (PubMed).

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