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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (pTyr700)

Details for Product anti-CBL Antibody No. ABIN319293, Supplier: Log in to see
Antigen
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
Alternatives
anti-Human CBL antibody for Western Blotting
Epitope
pTyr700
37
33
26
23
17
5
5
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
227
133
127
6
4
4
4
1
1
1
Host
Rabbit
189
33
9
1
Clonality
Polyclonal
Conjugate
This CBL antibody is un-conjugated
7
6
6
5
5
5
5
5
5
5
5
5
2
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
149
64
59
56
48
29
18
13
5
5
4
3
3
1
1
1
1
1
Supplier
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Immunogen Synthetic phosphopeptide derived from human c-Cbl around the phosphorylation site of Tyrosine 770 (T-E-YP-M-T).
Specificity This Antibody detects endogenous levels of c-Cbl only when phosphorylated at Tyrosine 770.
Purification Affinity Chromatography
Alternative Name CBL / RNF55 (CBL Antibody Abstract)
Background The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL's interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
Gene ID 867
NCBI Accession NP_005179
UniProt P22681
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (pTyr700) (ABIN319293) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (pTyr700) antibody
 image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (pTyr700) (ABIN319293) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (pTyr700) antibody (Image 2)
 image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (pTyr700) (ABIN319293) anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (pTyr700) antibody (Image 3)
Background publications Owen-Schaub, Chan, Cusack et al.: "Fas and Fas ligand interactions in malignant disease." in: International journal of oncology, Vol. 17, Issue 1, pp. 5-12, 2000 (PubMed).

Chen, Cizeau, Vande Velde et al.: "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins." in: The Journal of biological chemistry, Vol. 274, Issue 1, pp. 7-10, 1999 (PubMed).

Thien, Langdon: "c-Cbl: a regulator of T cell receptor-mediated signalling." in: Immunology and cell biology, Vol. 76, Issue 5, pp. 473-82, 1999 (PubMed).

Drivas, Shih, Coutavas et al.: "Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3." in: Oncogene, Vol. 6, Issue 1, pp. 3-9, 1991 (PubMed).