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CBL antibody (pTyr700)

CBL Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN319294
  • Target See all CBL Antibodies
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    Binding Specificity
    • 28
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    • 17
    • 9
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    pTyr700
    Reactivity
    • 171
    • 77
    • 65
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 151
    • 18
    • 3
    • 1
    Rabbit
    Clonality
    • 142
    • 31
    Polyclonal
    Conjugate
    • 76
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
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    • 6
    • 4
    • 4
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    This CBL antibody is un-conjugated
    Application
    • 82
    • 52
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    • 49
    • 32
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    • 9
    • 3
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This Antibody detects endogenous levels of c-Cbl only when phosphorylated at Tyrosine 770.
    Purification
    Affinity Chromatography
    Immunogen
    Synthetic phosphopeptide derived from human c-Cbl around the phosphorylation site of Tyrosine 770 (T-E-YP-M-T).
    Top Product
    Discover our top product CBL Primary Antibody
  • Application Notes
    Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at-20 °C.
  • Target
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    Alternative Name
    CBL / RNF55 (CBL Products)
    Synonyms
    4732447J05Rik antibody, Cbl-2 antibody, c-Cbl antibody, cbl antibody, C-CBL antibody, CBL2 antibody, FRA11B antibody, NSLL antibody, RNF55 antibody, c-cbl-like antibody, RGD1561386 antibody, Casitas B-lineage lymphoma antibody, Cbl proto-oncogene antibody, Cbl antibody, CBL antibody
    Background
    The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL's interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
    Gene ID
    867
    NCBI Accession
    NP_005179
    UniProt
    P22681
    Pathways
    TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
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