V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (Thr450) antibody

Details for Product No. ABIN319376
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Antigen
Synonyms
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, pkb, xAct, akt-1, v-akt, v-akt1, Akt, AKT1, ATAKT1, F18A8.2, F18A8_2, K+ transporter 1, POTASSIUM TRANSPORTER, AKT/PKB, Akt/PKB, Akt1, CG4006, D-Akt,  ... show more
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, pkb, xAct, akt-1, v-akt, v-akt1, Akt, AKT1, ATAKT1, F18A8.2, F18A8_2, K+ transporter 1, POTASSIUM TRANSPORTER, AKT/PKB, Akt/PKB, Akt1, CG4006, D-Akt, DAKT1, DAKT1/PKB, DAkt, DAkt1, DPKB, DRAC-PK, DRAC-PK66, DRAC-PK85, Dakt, Dakt1, Dmel\\CG4006, Dpkb, PKB/AKT, PKB/Akt, PKB/dAKT, RacPK, akt, akt1, dAKT, dAKT/dPKB, dAKT1, dAkt, dAkt/PKB, dAkt1, dPKB, dakt, dakt1, l(3)04226, l(3)89Bq, p-Akt, pAkt show less
Epitope
Thr450
(129), (88), (54), (50), (48), (33), (32), (29), (28), (17), (16), (16), (11), (9), (9), (8), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(837), (536), (513), (167), (153), (115), (94), (21), (18), (4), (3), (1), (1), (1), (1)
Host
Rabbit
(698), (144), (7), (5), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(20), (14), (13), (13), (13), (13), (13), (13), (13), (13), (13), (9), (7), (7), (7), (7), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(637), (361), (240), (160), (139), (130), (123), (66), (43), (17), (11), (5), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN319376
Quantity 50 µg
Price
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human AKT1 around the phosphorylation site of Threonine 450 (T-I-TP-P-P).
Specificity This antibody detects endogenous levels of total AKT1 protein.
Purification Immunoaffinity Chromatography.
Alternative Name AKT1 / PKB
Background The serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific. In the developing nervous system AKT is a critical mediator of growth factor induced neuronal survival. Survival factors can suppress apoptosis in a transcription independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene (referenced from entrez gene).
Alternate names: Akt-1, C-AKT, Protein kinase B, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase
Gene ID 207
NCBI Accession NP_001014431.1
UniProt P31749
Research Area Signaling, Protein Modifications, Kinases/Phosphatases
Application Notes Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/100. Immunofluorescence: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20°C.
Expiry Date 12 months
Supplier Images
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (Thr450) antibody anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (Thr450) antibody
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (Thr450) antibody (2) anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (Thr450) antibody (Image 2)
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (Thr450) antibody (3) anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (Thr450) antibody (Image 3)
Background publications Levin: "It's prime time for reverse transcriptase." in: Cell, Vol. 88, Issue 1, pp. 5-8, 1997 (PubMed).

Sarbassov, Guertin, Ali et al.: "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex." in: Science (New York, N.Y.), Vol. 307, Issue 5712, pp. 1098-101, 2005 (PubMed).

Hosts (698), (144), (7), (5), (4), (3)
Reactivities (837), (536), (513), (167), (153), (115), (94), (21), (18), (4), (3), (1), (1), (1), (1)
Applications (637), (361), (240), (160), (139), (130), (123), (66), (43), (17), (11), (5), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Conjugates (20), (14), (13), (13), (13), (13), (13), (13), (13), (13), (13), (9), (7), (7), (7), (7), (1), (1), (1), (1), (1), (1)
Epitopes (129), (88), (54), (50), (48), (33), (32), (29), (28), (17), (16), (16), (11), (9), (9), (8), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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