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Details for Product No. ABIN319385

Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) (Ser49) antibody

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Antigen
Synonyms
EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha, eif2, eif2s1, fb19d01, wu:fb19d01, eif2a, 35kDa, Eif2a, eIF2alpha, 0910001O23Rik, 2410026C18Rik, CG9946, Dmel\\CG9946, Eif2alpha, IF2A_DROME, M(1)14C, M(1)19-15 ... show more
Epitope
»Alternatives Ser49
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN319385
Quantity 0.1 mg
Price
313.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human eIF2a around the phosphorylation site of Serine 49 (L-L-SP-E -L).
Specificity This antibody detects endogenous levels of total elF2a protein.
Purification Immunoaffinity Chromatography.
Alternative Name EIF2A / EIF2S1
Background The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD), and gamma (52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha.
Alternate names: EIF2-A, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, eIF2 alpha
Gene ID 1965
NCBI Accession NP_004085.1
UniProt P05198
Application Notes Immunohistochemistry (1/50-1/100). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20°C.
Expiry Date 12 months
Background publications de Haro, Méndez, Santoyo: "The eIF-2alpha kinases and the control of protein synthesis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 10, Issue 12, pp. 1378-87, 1996 (PubMed).

Tabor: "Prions of mammals and fungi minireview series." in: The Journal of biological chemistry, Vol. 274, Issue 1, pp. 1, 1999 (PubMed).

Korpelainen, Kärkkäinen, Gunji et al.: "Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response." in: Oncogene, Vol. 18, Issue 1, pp. 1-8, 1999 (PubMed).

Kimball: "Eukaryotic initiation factor eIF2." in: The international journal of biochemistry & cell biology, Vol. 31, Issue 1, pp. 25-9, 1999 (PubMed).

Alternatives for antigen "Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1)", type "Antibodies"
Hosts (62), (23), (1)
Reactivities (76), (35), (35), (6), (5), (2), (2), (1), (1), (1), (1)
Applications (76), (37), (25), (21), (15), (12), (6), (3), (2), (2), (1), (1), (1)
Epitopes (12), (6), (5), (5), (5), (5), (3), (2), (2), (2), (1), (1), (1)
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