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Integrin beta 3 antibody (ITGB3) (PE)

Details for Product anti-ITGB3 Antibody No. ABIN319520, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Reactivity
Human
579
243
206
27
27
27
26
18
15
12
9
7
7
7
5
3
2
2
2
2
1
1
1
1
1
1
Host
Mouse
369
226
59
29
12
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is conjugated to PE
84
55
29
18
14
12
10
10
9
9
9
7
7
7
7
6
6
6
5
4
4
4
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS)
420
275
164
126
106
87
86
77
64
27
13
13
8
6
6
6
5
5
4
4
2
2
2
2
1
1
1
Options
Supplier
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Immunogen PHA stimulated peripheral blood cells. Spleen cells from immunised Balb/c mice were fused with cells of the NS1 myeloma cell line.
Clone Y2-51
Isotype IgG1
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD61 / ITGB3 (ITGB3 Antibody Abstract)
Background CD61 is a 105kD glycoprotein, which is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
Gene ID 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: use 10 μL of neat antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1.0 mL distilled water.
Concentration 0.1mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
Background publications Hynes: "Integrins: versatility, modulation, and signaling in cell adhesion." in: Cell, Vol. 69, Issue 1, pp. 11-25, 1992 (PubMed).

Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, 1991 (PubMed).

Gatter, Cordell, Turley, Heryet, Kieffer, Anstee, Mason: "The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens." in: Histopathology, Vol. 13, Issue 3, pp. 257-67, 1989 (PubMed).