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Mast/stem Cell Growth Factor Receptor (KIT) antibody (PE)

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Antigen
Alternatives
Reactivity
Mouse (Murine)
(813), (417), (129), (22), (16), (14), (14), (11), (2), (1)
Host
Rat
(647), (235), (215), (4), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(110), (88), (84), (71), (48), (40), (18), (14), (11), (11), (11), (8), (8), (8), (8), (8), (7), (6), (6), (5), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(386), (351), (338), (174), (136), (121), (92), (60), (42), (35), (18), (12), (11), (11), (8), (4), (4), (3), (2), (2), (2), (2), (2), (1)
Pubmed 2 references available
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Quantity 25 tests
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Immunogen IL-3 dependent mast cells. Spleen cells from immunised Wistar rats were fused with cells of the Fox-NY mouse myeloma cell line.
Clone 2B8
Isotype IgG2b
Specificity This antibody reacts with CD117 also known as Kit or c-kit receptor. Clone 2B8 recognises an epitope within the extracellular region of CD117.
Purification Purified IgG prepared by affinity chromatography on Protein A.
Alternative Name CD117 / C-Kit (KIT Antibody Abstract)
Background CD117 is the receptor of the steel factor (Stem Cell Factor). C-kit receptor is expressed on 5-10 % of total adult bone marrow cells including multipotent hematopoietic cells.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID 16590
NCBI Accession NP_066922
UniProt P05532
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors, Receptors, Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Flow Cytometry: Use 10 μL of neat antibody to label 10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with distilled water.
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Fleming, Alpern, Uchida et al.: "Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3760-4, 1993 (PubMed).

Ikuta, Weissman: "Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 4, pp. 1502-6, 1992 (PubMed).

Catalog No. ABIN319618

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