IFNG antibody (Interferon gamma)

Details for Product anti-IFNG Antibody No. ABIN319646, Supplier: Log in to see
Antigen
  • IFNG2
  • IFN-g
  • Ifg
  • IFN-G
  • IFN-gamma
  • IFNG
  • IFG
  • IFI
  • interferon gamma
  • interferon gamma-like
  • interferon, gamma
  • Ifng
  • IFNG
  • LOC101337436
Alternatives
anti-Rat (Rattus) IFNG antibody for ELISpot
Reactivity
Mouse (Murine)
778
278
145
71
47
42
32
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31
24
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22
18
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10
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2
1
1
Host
Rat
715
397
192
31
8
6
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3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This IFNG antibody is un-conjugated
155
115
73
50
37
26
26
20
17
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11
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2
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Application
Functional Studies (Func), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)
712
658
514
185
135
128
92
87
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64
49
43
38
31
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2
2
2
2
1
1
1
1
1
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1
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Options
Supplier
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Supplier Product No.
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Clone XMG1-2
Isotype IgG1
Specificity This antibody recognizes gamma IFN. The antibody has been shown to block the functional activity of Mouse IFN gamma.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Endotoxin Level < 0.01EU/μg
Alternative Name IFNG / Interferon gamma (IFNG Antibody Abstract)
Background Interferon gamma is mainly produced by T lymphocytes and NK cells. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses,including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak antiviral and antiproliferative activity, and poteniates the antiviral and anti tumor effects of IFN alpha / beta (type I interferon). It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Labile at pH 2.Synonyms: IFN-gamma, gamma IFN
Gene ID 15978
NCBI Accession NP_032363
UniProt P01580
Pathways Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy
Application Notes ELISA. Flow Cytometry. Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Endotoxin Level < 0.01EU/ug
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
Background publications Rountree, Mandl, Nachtwey, Dalpozzo, Do, Lombardo, Schoonmaker, Brinkmann, Dirmeier, Laus, Delcayre: "Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy." in: Cancer research, Vol. 71, Issue 15, pp. 5235-44, 2011 (PubMed).

Chiu, Wang, Chien, Hou, Hu, Yeh: "Effects of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in hypercholesterolemic mice with sepsis." in: The Journal of nutritional biochemistry, Vol. 20, Issue 4, pp. 254-60, 2009 (PubMed).

Hsu, Chiu, Yeh, Hou, Chou, Yeh: "Dietary fish oil enhances adhesion molecule and interleukin-6 expression in mice with polymicrobial sepsis." in: The British journal of nutrition, Vol. 96, Issue 5, pp. 854-60, 2006 (PubMed).

Holz, Brett, Oldstone: "Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes." in: The Journal of clinical investigation, Vol. 108, Issue 12, pp. 1749-58, 2001 (PubMed).

Hsieh, Schrenzel, Mulvania, Lepper, DiMolfetto-Landon, Ferrick: "In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 1, pp. 232-7, 1996 (PubMed).

Luo, Freitag, Sachs: "Translational regulation in response to changes in amino acid availability in Neurospora crassa." in: Molecular and cellular biology, Vol. 15, Issue 10, pp. 5235-45, 1995 (PubMed).

Cherwinski, Schumacher, Brown, Mosmann et al.: "Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal ..." in: The Journal of experimental medicine, Vol. 166, Issue 5, pp. 1229-44, 1987 (PubMed).

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