Interferon gamma (IFNG) antibody

Details for Product No. ABIN319646
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Antigen
Synonyms IFNG2, IFN-g, Ifg, IFN-G, IFN-gamma, IFNG, IFG, IFI
Reactivity
Mouse (Murine)
(356), (157), (87), (27), (20), (15), (10), (9), (7), (5), (5), (5), (4), (4), (3), (3), (1), (1)
Host
Rat
(297), (205), (100), (19), (5), (4), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(78), (53), (22), (14), (13), (10), (5), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2), (1)
Application
ELISA, Functional Studies (Func), Flow Cytometry (FACS)
(391), (334), (170), (74), (60), (58), (56), (48), (44), (37), (30), (29), (19), (11), (10), (9), (7), (5), (5), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Pubmed 7 references available
Quantity 0.5 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN319646
478.50 $
Plus shipping costs $45.00

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Clone XMG1-2
Isotype IgG1
Specificity This antibody recognizes gamma IFN. The antibody has been shown to block the functional activity of Mouse IFN gamma.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Endotoxin Level Low Endotoxin
Alternative Name IFNG / Interferon gamma
Background Interferon gamma is mainly produced by T lymphocytes and NK cells. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses,including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak antiviral and antiproliferative activity, and poteniates the antiviral and anti tumor effects of IFN alpha / beta (type I interferon). It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Labile at pH 2.
Alternate names: IFN-gamma, gamma IFN
Gene ID 15978
NCBI Accession NP_032363
UniProt P01580
Application Notes ELISA. Flow Cytometry. Functional Assays. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Endotoxin Level < 0.01EU/ug
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 without preservatives. Endotoxin Level: less than 0.01EU/µg
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20°C. Following reconstitution the antibody can be stored at 2-8°C for one month or at -20°C for longer.
Expiry Date 12 months
Background publications Cherwinski, Schumacher, Brown et al.: "Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies." in: The Journal of experimental medicine, Vol. 166, Issue 5, pp. 1229-44, 1987 (PubMed).

Luo, Freitag, Sachs: "Translational regulation in response to changes in amino acid availability in Neurospora crassa." in: Molecular and cellular biology, Vol. 15, Issue 10, pp. 5235-45, 1995 (PubMed).

Hsieh, Schrenzel, Mulvania et al.: "In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 1, pp. 232-7, 1996 (PubMed).

Holz, Brett, Oldstone: "Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes." in: The Journal of clinical investigation, Vol. 108, Issue 12, pp. 1749-58, 2001 (PubMed).

Hsu, Chiu, Yeh et al.: "Dietary fish oil enhances adhesion molecule and interleukin-6 expression in mice with polymicrobial sepsis." in: The British journal of nutrition, Vol. 96, Issue 5, pp. 854-60, 2006 (PubMed).

Chiu, Wang, Chien et al.: "Effects of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in hypercholesterolemic mice with sepsis." in: The Journal of nutritional biochemistry, Vol. 20, Issue 4, pp. 254-60, 2009 (PubMed).

Rountree, Mandl, Nachtwey et al.: "Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy." in: Cancer research, Vol. 71, Issue 15, pp. 5235-44, 2011 (PubMed).

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