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IFNG antibody (Interferon gamma)

Details for Product anti-IFNG Antibody No. ABIN319646, Supplier: Log in to see
Antigen
  • IFNG2
  • IFN-g
  • Ifg
  • IFN-G
  • IFN-gamma
  • IFNG
  • IFG
  • IFI
Alternatives
anti-Mouse (Murine) IFNG antibody for Enzyme Immunoassay
Reactivity
Mouse (Murine)
613
263
145
57
35
25
20
20
13
13
12
11
9
9
9
9
7
6
6
6
6
6
5
2
1
1
1
Host
Rat
527
389
166
30
8
7
4
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
This IFNG antibody is un-conjugated
156
112
61
46
35
12
10
10
9
6
5
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Functional Studies (Func), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)
624
551
349
123
117
114
68
60
48
40
37
37
37
32
29
17
14
9
9
8
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7
7
4
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
Supplier
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Clone XMG1-2
Isotype IgG1
Specificity This antibody recognizes gamma IFN. The antibody has been shown to block the functional activity of Mouse IFN gamma.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Endotoxin Level < 0.01EU/μg
Alternative Name IFNG / Interferon gamma (IFNG Antibody Abstract)
Background Interferon gamma is mainly produced by T lymphocytes and NK cells. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses,including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak antiviral and antiproliferative activity, and poteniates the antiviral and anti tumor effects of IFN alpha / beta (type I interferon). It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. Labile at pH 2.Synonyms: IFN-gamma, gamma IFN
Gene ID 15978
NCBI Accession NP_032363
UniProt P01580
Pathways Interferon-gamma Pathway
Application Notes ELISA. Flow Cytometry. Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Endotoxin Level < 0.01EU/ug
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
Background publications Rountree, Mandl, Nachtwey et al.: "Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy." in: Cancer research, Vol. 71, Issue 15, pp. 5235-44, 2011 (PubMed).

Chiu, Wang, Chien et al.: "Effects of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in hypercholesterolemic mice with sepsis." in: The Journal of nutritional biochemistry, Vol. 20, Issue 4, pp. 254-60, 2009 (PubMed).

Hsu, Chiu, Yeh et al.: "Dietary fish oil enhances adhesion molecule and interleukin-6 expression in mice with polymicrobial sepsis." in: The British journal of nutrition, Vol. 96, Issue 5, pp. 854-60, 2006 (PubMed).

Holz, Brett, Oldstone: "Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes." in: The Journal of clinical investigation, Vol. 108, Issue 12, pp. 1749-58, 2001 (PubMed).

Hsieh, Schrenzel, Mulvania et al.: "In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 1, pp. 232-7, 1996 (PubMed).

Luo, Freitag, Sachs: "Translational regulation in response to changes in amino acid availability in Neurospora crassa." in: Molecular and cellular biology, Vol. 15, Issue 10, pp. 5235-45, 1995 (PubMed).

Cherwinski, Schumacher, Brown et al.: "Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal ..." in: The Journal of experimental medicine, Vol. 166, Issue 5, pp. 1229-44, 1987 (PubMed).