CD48 antibody (CD48 Molecule) (PE)

Details for Product anti-CD48 Antibody No. ABIN319758, Supplier: Log in to see
Antigen
  • AI449234
  • AW610730
  • BCM1
  • BLAST
  • BLAST-1
  • BLAST1
  • Bcm-1
  • MEM-102
  • SLAMF2
  • Sgp-60
  • hCD48
  • mCD48
  • CD48 antigen
  • Cd48 molecule
  • CD48 molecule
  • Cd48
  • CD48
Reactivity
Human, Monkey
200
127
33
16
9
5
5
2
1
1
1
1
Host
Mouse
174
60
59
42
4
4
Clonality (Clone)
Monoclonal ()
Conjugate
This CD48 antibody is conjugated to PE
42
41
18
17
8
8
7
6
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS)
265
89
49
34
31
28
23
12
9
5
4
4
3
3
3
2
2
2
1
1
1
Options
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Clone MEM-102
Isotype IgG1
Specificity This antibody binds to the 45 kDa leucocyte surface glycoprotein specific for the CD48 antigen which is closely related to the activation antigen, Blast-1. It is useful in the detection of CD48 positive cells and may be used in studies to differentiate haemapoietic tumours, sarcomas and melanomas.
Purification Affinity Chromatography on Protein A
Alternative Name CD48 (CD48 Antibody Abstract)
Background CD48 is a glycosyl phophatidyl inositol (GPI) anchored cell surface protein also known as Blast1, HuLy m3, BCM1 (in mouse), and OX45 (in rat). CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibrolasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2. The CD48 antigen is closely related to the activation antigen, Blast 1.Synonyms: B-lymphocyte activation marker BLAST-1, BCM1, BCM1 surface antigen, BLAST1, Leukocyte antigen MEM-102, MEM-102, TCT.1
Gene ID 962
NCBI Accession NP_001769
UniProt P09326
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with distilled water.
Buffer PBS, pH 7.4, 0.09 % Sodium Azide, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
Background publications Staffler, Szekeres, Schütz, Säemann, Prager, Zeyda, Drbal, Zlabinger, Stulnig, Stockinger: "Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 4, pp. 1707-14, 2003 (PubMed).

Cinek, Horejsí: "The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 7, pp. 2262-70, 1992 (PubMed).

Korínek, Stefanová, Angelisová, Hilgert, Horejsí: "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1." in: Immunogenetics, Vol. 33, Issue 2, pp. 108-12, 1991 (PubMed).