Integrin alpha 1 (ITGA1) antibody

Details for Product No. ABIN319761
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Synonyms CD49A, E130012M19Rik, Vla1, CD49a, VLA1
(90), (25), (25), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(56), (37), (3), (2)
Clonality (Clone)
Monoclonal ()
(8), (8), (8), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
(57), (31), (28), (18), (17), (13), (12), (10), (6), (3), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.5 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN319761
555.50 $
Plus shipping costs $45.00

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Clone TS2-7
Isotype IgG1
Purification Affinity Chromatography on Protein A.
Alternative Name CD49a / ITGA1
Background Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Alpha 1 integrin along with alpha 2, alpha L and alpha M has a unique inserted domain. Integrin alpha 1 is a receptor for laminin and collagen. The alpha1 subunit is also known as CD49a. CD49a associates with CD29 (beta 1 integrin), to form an alpha1 beta1 heterodimer, identified as the rat homologue to VLA1, which is involved in cellular adhesion to laminin and collagen.Synonyms: CD49 antigen-like family member A, ITGA-1, Integrin alpha-1, Laminin and Collagen Receptor, VLA-1, VLA1
Gene ID 3672
NCBI Accession NP_852478
UniProt P56199
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 5 μL of neat antibody to label 10^6 cells in 100 μL. Immunoprecipitation. Immunohistochemistry on Frozen Sections. This clone has been reported as being suitable for use in Western Blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 20 µg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Background publications Hemler, Sanchez-Madrid, Flotte et al.: "Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 132, Issue 6, pp. 3011-8, 1984 (PubMed).

Hafler, Hemler, Christenson et al.: "Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases." in: Clinical immunology and immunopathology, Vol. 37, Issue 2, pp. 163-71, 1985 (PubMed).

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