Toll-Like Receptor 2 (TLR2) antibody

Details for Product No. ABIN320046
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Antigen
Synonyms TIL4, CD282, Ly105
Reactivity
Human
(271), (122), (18), (17), (13), (13), (12), (3), (1), (1), (1)
Host
Mouse
(220), (72), (35), (6), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(43), (42), (28), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
(204), (122), (75), (74), (43), (37), (31), (30), (26), (25), (20), (10), (3), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN320046
Quantity 25 µg
Price
253.00 $   Plus shipping costs $45.00
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Immunogen CHO cell line transfected with human TLR2 (CD282).
Clone TLR2-3
Isotype IgG2a
Specificity This antibpody recognises human toll-like receptor 2 (TLR2), a 90kD type 1 transmembrane protein that is primarily expressed by peripheral blood monocytes. TLR2, also known as CD282, is reported to respond to a diverse range of bacterial cell wall components, mediating the innate immune response in co-operation with MD-2.
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name CD282 / TLR2
Background TLR2 is a member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognise pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram positive bacteria and yeast via stimulation of NF kappaB.
Alternate names: Toll-like receptor 2
NCBI Accession 9606
UniProt O60603
Research Area Signaling, Immunology, Inflammation
Application Notes Immunohistology-Frozen. Flow Cytometry: Use 10ul of the suggested working dilution to label 10e6 cells in 100ul. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Lien, Sellati, Yoshimura et al.: "Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33419-25, 1999 (PubMed).

Flo, Halaas, Torp et al.: "Differential expression of Toll-like receptor 2 in human cells." in: Journal of leukocyte biology, Vol. 69, Issue 3, pp. 474-81, 2001 (PubMed).

Hosts (220), (72), (35), (6), (5)
Reactivities (271), (122), (18), (17), (13), (13), (12), (3), (1), (1), (1)
Applications (204), (122), (75), (74), (43), (37), (31), (30), (26), (25), (20), (10), (3), (1), (1), (1)
Conjugates (43), (42), (28), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (21), (6), (5), (5), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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