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E2F1 antibody (pSer364)
E2F1
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
#2
unconjugated
Product Details anti-E2F1 Antibody
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Target
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E2F1
(E2F Transcription Factor 1 (E2F1))
Binding Specificity
All epitopes for E2F1 antibodies
pSer364
Reactivity
All reactivities for E2F1 antibodies
Human
Host
All hosts for E2F1 antibodies
Mouse
Clonality
All clonalities for E2F1 antibodies
Monoclonal
Conjugate
All conjugates for E2F1 antibodies
This E2F1 antibody is un-conjugated
Application
All applications for E2F1 antibodies
Western Blotting (WB), ELISA
Characteristics
Product: Mouse monoclonal antibody (clone #2) specific to the human E2F1 protein phosphorylated at Ser364. Produced in serum-free medium and purified under mild conditions
Purification
Purified
Immunogen
A synthetic peptide corresponding to a sequence of human E2F1 protein including and surrounding pSer364
Clone
#2
Isotype
IgG2b kappa
Top Product
Discover our top product E2F1 Primary Antibody
Alternatives
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Application Details
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Application Notes
1. Western blotting: ~1 g/mL 2. ELISA Not tested for other applications.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS (-), 50 % glycerol
Preservative
Azide free
Storage
-20 °C/-80 °C
Storage Comment
-20 C (For long term storage: -70 C)
References for anti-E2F1 antibody (ABIN3201010)
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Trimarchi, Lees : "Sibling rivalry in the E2F family. " in: Nature reviews. Molecular cell biology , Vol. 3 , Issue 1 , pp. 11-20 , (2002 ) (PubMed ).
Irwin, Marin, Phillips, Seelan, Smith, Liu, Flores, Tsai, Jacks, Vousden, Kaelin : "Role for the p53 homologue p73 in E2F-1-induced apoptosis. " in: Nature , Vol. 407 , Issue 6804 , pp. 645-8 , (2000 ) (PubMed ).
Target Details for E2F1
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Target
E2F1
(E2F Transcription Factor 1 (E2F1))
Alternative Name
E2F1 (E2F1 Products )
Synonyms
CG6376 antibody, DRTF1/E2F antibody, DmE2F-1 antibody, Dmel\\CG6376 antibody, Dp antibody, E(Sev-CycE)3A antibody, E(var)3-93E antibody, E(var)3-95E antibody, E(var)93E antibody, E2F antibody, E2F-1 antibody, E2F1 antibody, E2f1 antibody, Evar(3)164 antibody, dE2F antibody, dE2F1 antibody, dE2f antibody, dE2f1 antibody, de2f1 antibody, def21 antibody, drosE2F1 antibody, e2f antibody, e2f1 antibody, l(3)07172 antibody, l(3)j3B1 antibody, l(3)j3C2 antibody, l(3)rM729 antibody, RBAP1 antibody, RBBP3 antibody, RBP3 antibody, mKIAA4009 antibody, xE2F antibody, ATE2FB antibody, E2F TRANSCRIPTION FACTOR-1 E2F1 antibody, E2F transcription factor 1 antibody, E2FB antibody, E2FB TRANSCRIPTION FACTOR antibody, E2F transcription factor 1 antibody, E2F transcription factor 1 L homeolog antibody, E2f1 antibody, E2F1 antibody, e2f1.L antibody
Background
E2F1 is a member of E2F group of proteins that share common structural and functional domains and plays a major role during the G1/S transition in the mammalian cell cycle as a transcriptional factor. E2F1 is regulated during cell cycle progression. It is phosphorylated at Ser364 by Chk2 kinase in response to DNA damage, stabilized, mobilized to nucleus and activated as a transcription factor. It induces apoptosis by activating transcription of the p53 homolog, p73. E2F1 protein consists of 437 amino acids with a molecular mass of 46 kDa.
UniProt
Q01094
Pathways
p53 Signaling , Cell Division Cycle , Mitotic G1-G1/S Phases , DNA Replication , M Phase , Autophagy
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