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Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) antibody (FITC)

Details for Product No. ABIN320181
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Antigen
Synonyms B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7, Cd20, Ly-44, Ms4a2, AA960661, MS4A1, bp35, cd20, ms4a2, leu-16, ms4a4c, cd20-like
Reactivity
Human
(381), (43), (31), (30), (26), (24), (6), (6), (2)
Host
Mouse
(286), (95), (8), (4), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(40), (27), (21), (16), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(220), (96), (86), (58), (56), (51), (50), (21), (20), (11), (7), (3), (1), (1)
Pubmed 4 references available
Quantity 25 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN320181
198.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen NS-O cells transfected with human CD20. Spleen cells from immunised BALB/c mice were fused with cells of the mouse myeloma cell line NS1.
Clone AT80
Isotype IgG1
Specificity SM2154F recognises the human CD20 cell surface antigen, a glycoprotein of 35-37kD.
Purification Affinity Chromatography on Protein A.
Alternative Name CD20
Background The CD20 antigen is expressed during pre-B-cell development. The CD20 antigen is present on both resting and activated B-cells but is lost prior to terminal B-cell differentiation into plasma cells. The CD20 molecule is thought to have a possible involvement in ion transport.
Alternate names: B-cell marker, B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leu-16, MS4A1, Membrane-spanning 4-domains subfamily A member 1
Gene ID 931
NCBI Accession NP_068769.2
UniProt P11836
Research Area Cancer, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 10 ul of neat-1/10 diluted antibody to label 10e6 cells or 100 ul whole blood. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS, pH 7.2 with 0.09% Sodium Azide as preservative and 1% BSA as stabiliser.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zarkesh-Esfahani, Pockley, Metcalfe et al.: "High-dose leptin activates human leukocytes via receptor expression on monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 8, pp. 4593-9, 2001 (PubMed).

Polyak, Deans: "Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence..." in: Blood, Vol. 99, Issue 9, pp. 3256-62, 2002 (PubMed).

Cragg, Morgan, Chan et al.: "Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts." in: Blood, Vol. 101, Issue 3, pp. 1045-52, 2003 (PubMed).

Chan, Hughes, French et al.: "CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts." in: Cancer research, Vol. 63, Issue 17, pp. 5480-9, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN320181
198.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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