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Details for Product No. ABIN320263

Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) antibody

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Synonyms CD314, D12S2489E, KLR, NKG2-D, NKG2D, Nkrp2, KLRK1, Nkg2d, D6H12S2489E
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunoprecipitation (IP), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN320263
Quantity 25 µg
165.00 $   Plus shipping costs $45.00
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Immunogen NKL cells. Spleen cells from immunised RBF/DnJ mice were fused with cells of the p3 mouse myeloma cell line.
Clone 5C6
Isotype IgG2a
Specificity This antibody is specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). Clone 5C6 is reported to inhibit T cell recognition of MICA (1, 3). We recommend the use of SM2259LE for such studies.
Purification Affinity Chromatography on Protein G.
Alternative Name CD314 / KLRK1
Background CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells.
Alternate names: D12S2489E, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2D
Gene ID 100528032
NCBI Accession NP_001186734.1
UniProt P26718
Application Notes Flow Cytometry: Use 10 ul of 1/100-1/200 diluted antibody to label 10e6 cells in 100 ul. Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Bauer, Groh, Wu et al.: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 727-9, 1999 (PubMed).

Wu, Song, Bakker et al.: "An activating immunoreceptor complex formed by NKG2D and DAP10." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 730-2, 1999 (PubMed).

Das, Sugita, Brenner: "Mechanisms of Vdelta1 gammadelta T cell activation by microbial components." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 11, pp. 6578-86, 2004 (PubMed).

Alternatives for antigen "Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1)", type "Antibodies"
Hosts (46), (45), (32), (27), (9), (1)
Reactivities (94), (81), (20)
Applications (134), (29), (27), (21), (13), (10), (9), (4), (4), (4), (3), (1)
Conjugates (20), (17), (13), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (4)