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Details for Product No. ABIN320317

Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody (FITC)

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Antigen
Synonyms B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, Lca, RT7, Cd45, Ly-5, Lyt-4, loc, cd45, PTPRC, si:dkeyp-47c5.1
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Flow Cytometry (FACS)
Pubmed 5 references available
Catalog no. ABIN320317
Quantity 0.5 mg
Price
709.50 $   Plus shipping costs $45.00
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Immunogen Rat thymocyte membrane glycoproteins. Spleen cells from immunised BALB/c mice were fused with cells of the NS1 mouse myeloma cell line.
Clone OX-1
Isotype IgG1
Specificity This antibody recognises CD45. Antibodies recognising a common epitope on all of these isoforms are termed CD45, whilst those recognising only individual isoforms are termed CD45RA, CD45RO etc. OX-1 reacts with all forms of CD45 expressed by all haematopoietic cells, except erythrocytes.
Alternative Name CD45 / LCA
Background The leucocyte common antigen consists of a family of heavily glycosylated membrane glycoproteins of molecular weight 180 - 240kDa. CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.
Alternate names: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Gene ID 24699
NCBI Accession NP_001103357.1
UniProt P04157
Application Notes Flow Cytometry: Use 10 ul of 1/50 diluted antibody to label 10e6 cells in 100 ul. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Sunderland, McMaster, Williams: "Purification with monoclonal antibody of a predominant leukocyte-common antigen and glycoprotein from rat thymocytes." in: European journal of immunology, Vol. 9, Issue 2, pp. 155-9, 1979 (PubMed).

Woollett, Barclay, Puklavec et al.: "Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes." in: European journal of immunology, Vol. 15, Issue 2, pp. 168-73, 1985 (PubMed).

Martín, Molina, Bricio et al.: "Passive dual immunization against tumour necrosis factor-alpha (TNF-alpha) and IL-1 beta maximally ameliorates acute aminonucleoside nephrosis." in: Clinical and experimental immunology, Vol. 99, Issue 2, pp. 283-8, 1995 (PubMed).

Murakami, Sato, Nagasawa et al.: "Regulation of mast cell signaling through high-affinity IgE receptor by CD45 protein tyrosine phosphatase." in: International immunology, Vol. 12, Issue 2, pp. 169-76, 2000 (PubMed).

Sato, Balla, Otterbein et al.: "Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 6, pp. 4185-94, 2001 (PubMed).

Alternatives for antigen "Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)", type "Antibodies"
Hosts (754), (464), (122), (2), (1)
Reactivities (681), (483), (145), (58), (46), (41), (37), (24), (22), (12), (7), (5), (5), (3), (2), (2), (1), (1), (1)
Applications (1077), (269), (263), (195), (191), (117), (91), (85), (67), (56), (40), (14), (10), (7), (4), (2), (2), (2), (1), (1), (1), (1)
Conjugates (196), (136), (130), (65), (26), (21), (11), (10), (9), (9), (9), (9), (8), (7), (7), (6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (10), (6), (5), (5), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1)
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