Chemokine (C-C Motif) Ligand 20 (CCL20) antibody

Antigen: Chemokine (C-C Motif) Ligand 20 (CCL20)

Synonyms: CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20, CCL20, MIP-3ALPHA, si:dkey-150o13.1

Clonality: Monoclonal (YNR-HMIP3a)

Host: Mouse

Reactivity: Human

Application: ELISA

Catalog no.: ABIN334810

Additional Information

Alternative name: Macrophage Inflammatory Protein-3 alpha (CCL20)

Immunogen: recombinant Human MIP-3a.

Isotype: IgG1

Clone: YNR-HMIP3a

Description: Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6. Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-gamma, and down-regulated by IL-10. CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut. The gene for CCL20 (scya20) is located on chromosome 2 in humans. Synonyms: C-C motif chemokine 20, Small-inducible cytokine A20, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Liver and activation-regulated chemokine, CC chemokine LARC, Beta chemokine exodus-1, CCL20, CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20.

Application Details

Application Notes: By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).

Purification: Protein A.

Storage: Storage: Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at 20°C. Reconstitution: Reconstitute with 0.5ml of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf Life: Two years lyophilized, one month in solution at 4°C.

Restrictions: For Research Use only