Interleukin 4 (IL4) antibody

Antigen: Interleukin 4 (IL4)

Synonyms: BSF1, IL-4, BCGF1, BCGF-1, MGC79402, Il-4, IL4, Il4e12, IL-2, BSF-1

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Intracellular Staining (IS), Immunohistochemistry (IHC), Intracellular Staining (IS)

Catalog no.: ABIN334836

Additional Information

Alternative name: Interleukin-4

Immunogen: r.Human IL-4

Isotype: IgG2a  (Matching secondary antibodies)

Description: IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Synonyms: BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.

Application Details

Application Notes: In direct ELISA, using alkaline phosphatase goat anti-mouse Ig (Jackson Laboratories) 1:10,000 dilution will give 0.3 O.D. No cross reactivity with murine IL-4 was reported.

Concentration: 1mg/ml in PBS (after reconstitution)

Purification: Ion exchange

Storage: In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

Research Area: Cytokines, Receptors, Inflammation

Restrictions: For Research Use only