MAS1 Oncogene (MAS1) antibody

Antigen: MAS1 Oncogene (MAS1)

Synonyms: MAS, MGC119966, Mas-1, MAS1

Clonality: Monoclonal (15A10)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN335191

Additional Information

Alternative name: MAS1

Gene ID: 4142

Immunogen: Partial peptide of Human MAS1

Format: Affinity-purified

Isotype: IgG1, kappa chain  (Matching secondary antibodies)

Clone: 15A10

Description: MAS1/MAS is a member of G protein-coupled receptor and was first detected in vivo through its tumorigenic activity. MAS1 is expressed predominantly in testis and distinct areas of forebrain such as hippocampus and amygdala. MAS1 acts as a functional antagonist of AT1 (antgiotensin II type 1) receptor and modulates intracellular signaling of AT1 after angiotensin II stimulation, and binds Ang II metabolite Ang-(1-7). MAS1 may play a role in the regulation of blood pressure and cardiovascular homeostasis.

Application Details

Application Notes: WB: 20ug/ml, ELISA: 1ug/ml

Concentration: 0.25 mg/ml

Purification: ProteinG affinity purified

Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]

Storage: Store below -20C

Research Area: Cancer

Restrictions: For Research Use only

Images

Sample: lysates from human cancer cell lines. 1. Human adenocarcinoma cell line derived from lung cancer. 2. stomach, adenosquamous carcinoma 3. colon, adenocarcinoma 4. Human hepatoma cell line. 5. Human pancreatic ductal adenocarcinoma line 6. Human cell line derived from esophageal cancer. Squamous cell carcinoma. 7. Human metastatic mammary carcinoma cell line.

Publications

Publications: Alenina, Baranova, Smirnow et al.: "Cell type-specific expression of the Mas proto-oncogene in testis." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 50, Issue 5, pp. 691-6, 2002 (PubMed).

Santos, Simoes e Silva, Maric et al.: "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 14, pp. 8258-63, 2003 (PubMed).

Canals, Jenkins, Kellett et al.: "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS." in: The Journal of biological chemistry, Vol. 281, Issue 24, pp. 16757-67, 2006 (PubMed).