Keratin 14 (KRT14) antibody

Details for Product No. ABIN335216
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Synonyms Krt14, KRT14, CK14, ouro2, EBS3, EBS4, K14, NFJ, AI626930, Krt-1.14, Krt1-14, Ka14
Human, Rat (Rattus), Dog (Canine), Pig (Porcine)
(203), (37), (34), (11), (9), (5), (5), (3), (2)
(109), (94), (5)
Clonality (Clone)
Monoclonal ()
(8), (5), (1)
Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(131), (90), (62), (56), (45), (41), (39), (13), (4), (4), (4), (3), (1)
Pubmed 8 references available
Quantity 1 mL
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Immunogen RCK107 is a mouse monoclonal IgG3 antibody derived by fusion of SP2/0-Ag14 mouse myeloma cells with spleen cells from a mouse immunized with a cytoskeletal preparation of TR146 epithelial cells.
Clone RCK107
Isotype IgG1
Specificity Human, rat, canine and swine.
Purification Culture supernatant
Alternative Name Cytokeratin 14 / Keratin K14 (KRT14 Antibody Abstract)
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Application Notes RCK107 reacts exclusively with cytokeratin 14 which is present in basal cell compartments of stratified and combined epithelia. RCK107 is suitable for immunocytochemistry, immunohistochemistry on frozen sections and for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, flow cytometry and immunoblotting. Optimal antibody dilution should be determined by titration.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Supplier Images
Image no. 1 for anti-Keratin 14 (KRT14) antibody (ABIN335216) anti-Keratin 14 (KRT14) antibody
Image no. 2 for anti-Keratin 14 (KRT14) antibody (ABIN335216) anti-Keratin 14 (KRT14) antibody (Image 2)
Product cited in: Meek, Van Elssen, Huijskens et al.: "T cells fail to develop in the human skin-cell explants system, an inconvenient truth." in: BMC immunology, Vol. 12, Issue 1, pp. 17, 2011 (PubMed).

Background publications Vos, van den Ingh, Ramaekers et al.: "The expression of keratins, vimentin, neurofilament proteins, smooth muscle actin, neuron-specific enolase, and synaptophysin in tumors of the specific glands in the canine anal region." in: Veterinary pathology, Vol. 30, Issue 4, pp. 352-61, 1993 (PubMed).

Wetzels, Kuijpers, Lane et al.: "Basal cell-specific and hyperproliferation-related keratins in human breast cancer." in: The American journal of pathology, Vol. 138, Issue 3, pp. 751-63, 1991 (PubMed).

Smedts, Ramaekers, Troyanovsky et al.: "Keratin expression in cervical cancer." in: The American journal of pathology, Vol. 141, Issue 2, pp. 497-511, 1992 (PubMed).

Bauwens, De Groot, Ramaekers et al.: "Expression of intermediate filament proteins in the adult human vestibular labyrinth." in: The Annals of otology, rhinology, and laryngology, Vol. 101, Issue 6, pp. 479-86, 1992 (PubMed).

Wetzels, Schaafsma, Leigh et al.: "Laminin and type VII collagen distribution in different types of human lung carcinoma: correlation with expression of keratins 14, 16, 17 and 18." in: Histopathology, Vol. 20, Issue 4, pp. 295-303, 1992 (PubMed).

Smedts, Ramaekers, Troyanovsky et al.: "Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia." in: The American journal of pathology, Vol. 140, Issue 3, pp. 601-12, 1992 (PubMed).

Vos, van den Ingh, de Neijs et al.: "Immunohistochemistry with keratin monoclonal antibodies in canine tissues: urogenital tract, respiratory tract, (neuro-)endocrine tissues, choroid plexus and spinal cord." in: Zentralblatt für Veterinärmedizin. Reihe A, Vol. 39, Issue 10, pp. 721-40, 1993 (PubMed).

Catalog No. ABIN335216
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