Lamin B2 antibody (LMNB2)

Details for Product anti-LMNB2 Antibody No. ABIN335245, Supplier: Log in to see
Antigen
  • lmnb2-a
  • LMNB2
  • lmn2
  • lamb2
  • Lamin-L(II)
  • LOC100136040
  • im:7142331
  • lamin
  • wu:fb94e05
  • wu:fb95e12
  • wu:fc15d06
  • wu:fc49h03
  • lamin-b2
  • lmnb2
  • LAMB2
  • LMN2
  • RGD1563803
  • lamin B2
  • lmnb2-a
  • LMNB2
  • lmnb2
  • LOC100136040
  • lmnb2-b
  • Lmnb2
Alternatives
anti-Mouse (Murine) Lamin B2 antibody for Immunocytochemistry
Reactivity
Human, Mouse (Murine), Hamster, Xenopus laevis
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This Lamin B2 antibody is un-conjugated
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Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
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Options
Supplier
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Immunogen LN43 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with the detergent insoluble fraction of potoroo cell line PtK1.
Clone LN43
Isotype IgG1
Specificity Human, mouse, hamster and Xenopus.
Purification Culture supernatant
Alternative Name Lamin B2 (LMNB2 Antibody Abstract)
Background Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, ie lamin B1 and lamin B2.
Research Area Signaling, Cytoskeleton, Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes LN43 reacts with an epitope located in the C-terminal part of lamin B2. LN43 is suitable for immunohistochemistry on frozen sections, immunoblotting and flow cytometry and for staining with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent. Optimal antibody dilution should be determined by titration.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Product cited in: Broers, Machiels, Kuijpers, Smedts, van den Kieboom, Raymond, Ramaekers: "A- and B-type lamins are differentially expressed in normal human tissues." in: Histochemistry and cell biology, Vol. 107, Issue 6, pp. 505-17, 1997 (PubMed).

Jansen, Machiels, Hopman, Broers, Bot, Arends, Ramaekers, Schouten: "Comparison of A and B-type lamin expression in reactive lymph nodes and nodular sclerosing Hodgkin's disease." in: Histopathology, Vol. 31, Issue 4, pp. 304-12, 1997 (PubMed).

Machiels, Ramaekers, Kuijpers, Groenewoud, Oosterhuis, Looijenga: "Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults." in: The Journal of pathology, Vol. 182, Issue 2, pp. 197-204, 1997 (PubMed).

Machiels, Zorenc, Endert, Kuijpers, van Eys, Ramaekers, Broers: "An alternative splicing product of the lamin A/C gene lacks exon 10." in: The Journal of biological chemistry, Vol. 271, Issue 16, pp. 9249-53, 1996 (PubMed).

Machiels, Broers, Raymond, de Ley, Kuijpers, Caberg, Ramaekers: "Abnormal A-type lamin organization in a human lung carcinoma cell line." in: European journal of cell biology, Vol. 67, Issue 4, pp. 328-35, 1996 (PubMed).

Hozák, Sasseville, Raymond, Cook: "Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells." in: Journal of cell science, Vol. 108 ( Pt 2), pp. 635-44, 1995 (PubMed).

Jenkins, Hölman, Lyon, Lane, Stick, Hutchison: "Nuclei that lack a lamina accumulate karyophilic proteins and assemble a nuclear matrix." in: Journal of cell science, Vol. 106 ( Pt 1), pp. 275-85, 1994 (PubMed).

Bridger, Kill, OFarrell, Hutchison: "Internal lamin structures within G1 nuclei of human dermal fibroblasts." in: Journal of cell science, Vol. 104 ( Pt 2), pp. 297-306, 1993 (PubMed).

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