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E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN335288, Supplier: Login to see New
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E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc- ... show more
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc-1, CD324, CDHE, ECAD, LCAM, arc-1, cd324, cdhe, ecad, cdh1, si:dz180o5.2 show less
(439), (130), (93), (22), (20), (11), (6), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(260), (198), (19), (17), (2), (1)
Clonality (Clone)
Monoclonal ()
This E-cadherin antibody is un-conjugated
(30), (24), (16), (14), (10), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1)
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (IHC), Western Blotting (WB)
(320), (144), (101), (99), (99), (66), (52), (48), (43), (32), (13), (9), (6), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 8 references available
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Quantity 1 mL
Shipping to United States ( )
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Immunogen 6F9 is a mouse monoclonal IgG1 antibody obtained by fusion of P3-X63-Ag 8,653 mouse myeloma cells with spleen cells from a BABL/c mouse immunized with affinity purified 80 kD extracellular fragments of E-cadherin derived from tryptic digestion of A-431 human vulva carcinoma cells.
Clone 6F9
Isotype IgG1
Specificity Human.
Purification Culture supernatant
Alternative Name E-Cadherin / Cadherin-1 (CDH1 Antibody Abstract)
Background Cadherins constitute a family of transmembrane glycoproteins involved in Ca 2+ -dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. One of the best characterized cadherins is E-cadherin, a 120 kD transmembrane glycoprotein consisting of an 80 kD extracellular and a 40 kD transmembrane and cytoplasmic part. The extracellular domains of E-cadherin are responsible for calcium binding which allows for homophilic interaction with other E-cadherin molecules on the same cell and neighbouring cells. In addition, E-cadherin can interact heterophilically with integrin alpha E beta 7 . The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through the associated cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas E-cadherin is frequently downregulated, which is consistent with its function of an invasion suppressor in normal epithelia.
Application Notes 6F9 recognizes both the 120 kD E-cadherin and its 80 kD trypsin-resistant extracellular part. 6F9 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen sections when using a PBS buffer containing 0.1 mM CaCl 2 and 0.1 mM MgCl 2 and for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagentOptimal antibody dilution should be determined by titration.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Product cited in: Ghadimi, Behrens, Hoffmann et al.: "Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling." in: European journal of cancer (Oxford, England : 1990), Vol. 35, Issue 1, pp. 60-5, 1999 (PubMed).

Zschiesche, Schönborn, Behrens et al.: "Expression of E-cadherin and catenins in invasive mammary carcinomas." in: Anticancer research, Vol. 17, Issue 1B, pp. 561-7, 1997 (PubMed).

Mayer, Johnson, Leitl et al.: "E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration." in: Cancer research, Vol. 53, Issue 7, pp. 1690-5, 1993 (PubMed).

Böhm, Totzeck, Birchmeier et al.: "Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer." in: Clinical & experimental metastasis, Vol. 12, Issue 1, pp. 55-62, 1994 (PubMed).

Moll, Mitze, Frixen et al.: "Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas." in: The American journal of pathology, Vol. 143, Issue 6, pp. 1731-42, 1994 (PubMed).

Otto, Birchmeier, Schmidt et al.: "Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas." in: Cancer research, Vol. 54, Issue 12, pp. 3120-3, 1994 (PubMed).

Frixen, Behrens, Sachs et al.: "E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells." in: The Journal of cell biology, Vol. 113, Issue 1, pp. 173-85, 1991 (PubMed).

Schipper, Frixen, Behrens et al.: "E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis." in: Cancer research, Vol. 51, Issue 23 Pt 1, pp. 6328-37, 1991 (PubMed).

Catalog No. ABIN335288
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