anti-EPCAM antibody (Epithelial Cell Adhesion Molecule)

Details for Product anti-EPCAM Antibody No. ABIN335407
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Antigen
Synonyms
sb:cb6, tacstd, wu:fj17g02, zgc:110304, zgc:77119, tacstd1, MGC80540, EPCAM, TACSTD1, egp, ksa, m4s1, mk-1, cd326, egp40, mic18, trop1, ep-cam, hegp-2, co17-1a, ga733-2, GP40, LEU-9, TP41, Tp40, DIAR5 ... show more
sb:cb6, tacstd, wu:fj17g02, zgc:110304, zgc:77119, tacstd1, MGC80540, EPCAM, TACSTD1, egp, ksa, m4s1, mk-1, cd326, egp40, mic18, trop1, ep-cam, hegp-2, co17-1a, ga733-2, GP40, LEU-9, TP41, Tp40, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TROP1, CD326, EGP, Egp314, Ep-CAM, EpCAM1, GA733-2, Ly74, Tacsd1, Tacstd1, gp40 show less
Reactivity
Human
(294), (49), (33)
Host
Mouse
(217), (83), (16), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
This EPCAM antibody is un-conjugated
(27), (15), (11), (7), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(192), (114), (111), (85), (66), (61), (49), (48), (33), (11), (7), (5), (5), (5), (4), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Immunogen VU1D9 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with native Ep-CAM from lung tissue.
Clone VU1D9
Isotype IgG1
Specificity Human.
Purification Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Alternative Name Ep-CAM (EPCAM Antibody Abstract)
Background Ep-CAM is a 40 kD glycoprotein, which functions as an epithelial cell adhesion molecule. Ep-CAM mediates Ca 2+ -independent homotypic interactions. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is expressed in the majority of human carcinomas and is a marker for tumors of epithelial lineage.
Application Notes VU1D9 reacts with the first EGF repeat in the extracellular domain of Ep-CAM. The epitope is sensitive for reducing agents. VU1D9 detects Ep-CAM in most simple, pseudostratified and transitional epithelia and in the majority of human carcinomas. APPLICATIONS VU1D9 is suitable for immunoblotting (non-reducing conditions), immunocytochemistry and immuno-histochemistry on frozen and paraffin-embedded tissues and flow cytometry. Optimal antibody dilution should be determined by titration, recommended range is 1:25 - 1:200 for flow cytometry, and for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
Restrictions For Research Use only
Storage 4 °C
General Balzar, Winter, de Boer et al.: "The biology of the 17-1A antigen (Ep-CAM)." in: Journal of molecular medicine (Berlin, Germany), Vol. 77, Issue 10, pp. 699-712, 2000 (PubMed).

Validation Images
Catalog No. ABIN335407
328.00 $
Plus shipping costs $45.00
Quantity
Price
100 μg
328.00 $

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