Epithelial Cell Adhesion Molecule (EPCAM) antibody

Details for Product No. ABIN335407
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Antigen
Synonyms
sb:cb6, tacstd, wu:fj17g02, zgc:110304, zgc:77119, tacstd1, MGC80540, EPCAM, TACSTD1, egp, ksa, m4s1, mk-1, cd326, egp40, mic18, trop1, ep-cam, hegp-2, co17-1a, ga733-2, GP40, LEU-9, TP41, Tp40, DIAR5 ... show more
sb:cb6, tacstd, wu:fj17g02, zgc:110304, zgc:77119, tacstd1, MGC80540, EPCAM, TACSTD1, egp, ksa, m4s1, mk-1, cd326, egp40, mic18, trop1, ep-cam, hegp-2, co17-1a, ga733-2, GP40, LEU-9, TP41, Tp40, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TROP1, CD326, EGP, Egp314, Ep-CAM, EpCAM1, GA733-2, Ly74, Tacsd1, Tacstd1, gp40 show less
Reactivity
Human
(254), (64), (40), (17), (17), (17)
Host
Mouse
(175), (91), (13), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(25), (16), (10), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(144), (120), (97), (52), (51), (47), (44), (42), (30), (20), (5), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN335407
425.04 $
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Immunogen VU1D9 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with native Ep-CAM from lung tissue.
Clone VU1D9
Isotype IgG1
Specificity Human.
Purification Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Alternative Name Ep-CAM
Background Ep-CAM is a 40 kD glycoprotein, which functions as an epithelial cell adhesion molecule. Ep-CAM mediates Ca 2+ -independent homotypic interactions. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is expressed in the majority of human carcinomas and is a marker for tumors of epithelial lineage.
Application Notes VU1D9 reacts with the first EGF repeat in the extracellular domain of Ep-CAM. The epitope is sensitive for reducing agents. VU1D9 detects Ep-CAM in most simple, pseudostratified and transitional epithelia and in the majority of human carcinomas. APPLICATIONS VU1D9 is suitable for immunoblotting (non-reducing conditions), immunocytochemistry and immuno-histochemistry on frozen and paraffin-embedded tissues and flow cytometry. Optimal antibody dilution should be determined by titration, recommended range is 1:25 - 1:200 for flow cytometry, and for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
Restrictions For Research Use only
Storage 4 °C
General Balzar, Winter, de Boer et al.: "The biology of the 17-1A antigen (Ep-CAM)." in: Journal of molecular medicine (Berlin, Germany), Vol. 77, Issue 10, pp. 699-712, 2000 (PubMed).

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