CMKLR1 / ChemR23 (N-Term) antibody

Antigen: CMKLR1 / ChemR23 (N-Term)

Clonality: Monoclonal (BZ332)

Host: Rat

Reactivity: Human

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN337260

Additional Information

Swiss-Prot: Q99788

Immunogen: Peptide corresponding to an epitope within the N-terminal region of human CMKLR1.

Isotype: IgG2a  (Matching secondary antibodies)

Clone: BZ332

Description: Gene: CMKLR1 / ChemR23, Standard Gene Symbol: CMKLR1, Family: GPCR, Subfamily: Chemoattractant, Synonyms: CMKLR1, CHEMERINR, Chemokine-like receptor 1, ChemR23, DEZ, G protein-coupled receptor dez, Gpcr27, MGC126105, MGC126106

Specificity: Recognizes human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC's are recruited to sites of bleeding and tissue damage

Application Details

Application Notes: Flo (1:25 - 1:100), IHC-P (10 µg/ml)

Purification: Protein G Column

Buffer: PBS, pH 7.4, 0.09% sodium azide.

Storage: +4°C or -20°C, Avoid repeated freezing and thawing.

Restrictions: For Research Use only

Images

Human Placenta (formalin-fixed, paraffin-embedded) stained with CMKLR1 antibody ABIN337260 at 10 ug/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.