Na+-Taurocholate Cotransporting Polypeptide (NTCP) antibody

Antigen: Na+-Taurocholate Cotransporting Polypeptide (NTCP)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343362

Additional Information

Alternative name: Na+-taurocholate cotransporting polypeptide, NTCP

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human NTCP, identical to the related rat and mouse sequence.

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1 (Solute carrier family 10, member 1) is the major bile acid uptake system in human hepatocytes. NTCP and the ileal transporter ASBT (apical sodium-dependent bile acid transporter) are two sodium-dependent transporters critical for the enterohepatic circulation of bile acids. The hASBT gene is known to be activated by the glucocorticoid receptor (GR). 1 Ho RH et al. indicates functionally important polymorphisms in NTCP exist and that the likelihood of being carriers of such polymorphisms is dependent on ethnicity. 2

Specificity: Human, rat, mouse. No cross reactivity with other proteins.

Application Details

Application Notes: WB 1ug/ml (Rat liver), IHC-P 2ug/ml (Hu, Rat, Ms). Antigen Retrieval by heat

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Research Area: Transporters

Restrictions: For Research Use only

Images

anti-Na+-Taurocholate Cotransporting Polypeptide (NTCP) antibody