Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody

Antigen: Chemokine (C-X-C Motif) Receptor 4 (CXCR4)

Synonyms: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, MGC108696, CXCR4, MGC128682, cxcr4, cxcr4-B, CXC-R4-B, CXCR-4-B, MGC52882, MGC130802, fb22, hm89, lap3, lcr1, npyr, whim, cd184, lestr, npy3r, npyrl, CXC-R4, CXCR-4, hsy3rr, npyy3r, xcxcr4, d2s201e

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343363

Additional Information

Alternative name: CXCR4

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human CXCR4, different to the related rat sequence by two amino acids.

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. 1 CXCR4 is a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1, it functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. Tachibana et al. (1998) conclude that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization. 2

Specificity: Human, rat, mouse. No cross reactivity with other proteins.

Synonyms: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, MGC108696, CXCR4, MGC128682, cxcr4, cxcr4-B, CXC-R4-B, CXCR-4-B, MGC52882, MGC130802, fb22, hm89, lap3, lcr1, npyr, whim, cd184, lestr, npy3r, npyrl, CXC-R4, CXCR-4, hsy3rr, npyy3r, xcxcr4, d2s201e

Application Details

Application Notes: WB 1ug/ml (Hu, Rat Ms), IHC-P 2ug/ml (Hu). Antigen Retrieval by heat

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Research Area: Cancer, Adaptive Immunity, Hematopoietic Progenitors, Innate Immunity, Chemokines, Receptors

Restrictions: For Research Use only