Dopamine Receptor D1 (DRD1) antibody

Antigen: Dopamine Receptor D1 (DRD1)

Synonyms: D1R, Dop1, D1A, DRD1, DADR, DRD1A, drd1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB)

Catalog no.: ABIN343369

Additional Information

Alternative name: Dopamine receptor D 1 , DRD1

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human DRD1, identical to the related rat and mouse sequence.

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: Dopamine receptor D 1 , also known as DRD1, is a human gene. It is the most highly expressed DA receptor subtype among the DA receptor family. 1 Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. Dopamine D1 and D2 receptors are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia, and may also have a role in drug addiction and alcoholism. D1 receptors regulate neuron growth and differentiation, influence behaviour and modify dopamine D2 receptor-mediated events. And the presence of a D1 receptor gene restriction fragment length polymorphism will be helpful for future disease linkage studies. 2 DRD1 also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity. 3

Specificity: Human, rat, mouse No cross reactivity with other proteins.

Application Details

Application Notes: WB 1ug/ml (Hu, Rat, Ms)

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Restrictions: For Research Use only