Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) antibody

Antigen: Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1)

Synonyms: NR1, NMDA1, NMDAR1, grin1, nmda1, nmdar1, MGC145925, Nmdar1, GB19253, GRIN1, NMD-R1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343378

Additional Information

Alternative name: NMDAR1

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human NMDAR1, identical to the related rat and mouse sequence.

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: The NMDA receptor (NMDAR) is a specific type of ionotropic glutamate receptor. NMDA ( N -methyl D -aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. 1 It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. 2 The gene is a candidate for the site of the mutation in torsion dystonia. 3, 4 The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.

Specificity: Rat, mouse. No cross reactivity with other proteins.

Application Details

Application Notes: WB 1-2ug/ml (Rat, Ms, Hu). IHC-P 2ug/ml (Rat, Ms). Antigen Retrieval by heat, other application have not be tested.

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Research Area: Neurology, Neurotransmitters, Receptors

Restrictions: For Research Use only