Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) antibody

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A)

Synonyms: FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55, MGC19588, fpf, tbp1, p55-r, tnf-r, tnfar, tnfr1, cd120a, tnfr55, tnfr60, xtnfr1, zgc:85914, wu:fj65b10, TNFRSF1A, TNFR I, TNFRI, Tnfr1, TNF-R1, Tnfr-2, TNFRp55, TNF-alphaR1, TNFalpha-R1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Goat, Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343387

Additional Information

Alternative name: Tumor Necrosis Factor Receptor 1, TNFR1

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human TNFR1, different to the related rat sequence by a single amino acid.

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: Tumor necrosis factor receptor 1(TNFR1), a potent cytokine, elicits a broad spectrum of biologic responses which are mediated by binding to a cell surface receptor. Its gene is located on 12p13.2. The coding region and the 3-prime untranslated region of TNFR1 are distributed over 10 exons. 1 There are 2 different proteins that serve as major receptors for TNF-alpha, one associated with myeloid cells and one associated with epithelial cells. 2 Additionally, TNFR1 associates with the MADD protein through a death domain-death domain interaction. MADD provides a physical link between TNFR1 and the induction of mitogen-activated protein (MAP) kinase (e.g., ERK2) activation and arachidonic acid release. 3 TNFR1-induced apoptosis involves 2 sequential signaling complexes. Complex I, the initial plasma membrane-bound complex, consists of TNFR1, the adaptor TRADD, the kinase RIP1, and TRAF2 and rapidly signals activation of NF-kappa-B. In a second step, TRADD and RIP1 associate with FADD and caspase-8, forming a cytoplasmic complex, complex II. 4

Specificity: Goat, human, mouse, rat. No cross reactivity with other proteins.

Synonyms: FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55, MGC19588, fpf, tbp1, p55-r, tnf-r, tnfar, tnfr1, cd120a, tnfr55, tnfr60, xtnfr1, zgc:85914, wu:fj65b10, TNFRSF1A, TNFR I, TNFRI, Tnfr1, TNF-R1, Tnfr-2, TNFRp55, TNF-alphaR1, TNFalpha-R1

Application Details

Application Notes: WB 1ug/ml (Goat, Hu). IHC-P 0.5-1ug/ml (Goat, Hu, Rat, Ms). Antigen Retrieval by heat

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4 , 0.05mg Thimerosal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Restrictions: For Research Use only