Chemokine (C-C Motif) Receptor 6 (CCR6) antibody

Antigen: Chemokine (C-C Motif) Receptor 6 (CCR6)

Synonyms: BN-1, CKR6, DCR2, CD196, CKRL3, DRY-6, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, GPR-CY4, CCR-6, KY411, Cmkbr6, CC-CKR-6, MGC108876, CCR6

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343396

Additional Information

Alternative name: C-C Chemokine receptor 6, CCR6

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human CCR6, identical to the related rat and mouse sequence.

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: CCR6, also termed CKRL3, encodes a 369-amino acid polypeptide with greatest similarity to the family of alpha-chemokine-binding receptors 1 . Unlike most chemokine receptor genes, it is encoded by more than 1 exon 2 . Weakly expressed as a 4-kb transcript in spleen, lymph nodes, peripheral blood lymphocytes and appendix, CCR6 gene is located at 6q27. As the receptor for MIP-3-alpha, its activation leads to phospholipase C-dependent intracellular Ca(2+) mobilization. Additionally, CCR6 are markedly upregulated in psoriasis 3 .

Specificity: Human, mouse, rat. No cross reactivity with other proteins.

Application Details

Application Notes: WB 0.75ug/ml (Hu, Rat, Ms). IHC-P 0.5-1ug/ml (Hu, Rat, Ms). Antigen Retrieval by heat

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Restrictions: For Research Use only