Lamin A/C (LMNA) antibody

Antigen: Lamin A/C (LMNA)

Synonyms: FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, PRO1, CDCD1, CMD1A, CMT2B1, LGMD1B, Dhe, 2459, 74/76, CG6944, D5, Dm, Dm(0), Dm0, Dm1, Dm2, DmelCG6944, DmLamin, Dmo, DmO, Dm[[0]], Dm[[1]], Dm[[2]], Dm[[mit]], Dm[[o]], DM[[O]], jf27, l(2)04643, l(2)25Ec, l(2)gdh-7, l(2)gdh7, l(2)jf27, lam, Lam Dm[[0]], Lam(Dm0), lamDm0, LamDm[[0], lamDm[[0]], LamDm[[0]], lamin, lamin Dm0, lamin Dm[[0]], Lamin Dm[[0]], Lam[[Dm0]], misg, nlam, cb948, fk66d12, wu:fk66d12, lmna-A, MGC127505, LMNA, fpl, idc, lfp, cddc, emd2, fpld, hgps, ldp1, lmn1, lmnc, pro1, cdcd1, cmd1a, cmt2b1, lgmd1b, Lamin-A

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343423

Additional Information

Alternative name: Lamin A/C

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human Lamin A/C, identical to the related rat and mouse sequence.

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.

Specificity: Human, mouse, rat. No cross reactivity with other proteins.

Synonyms: FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, PRO1, CDCD1, CMD1A, CMT2B1, LGMD1B, Dhe, 2459, 74/76, CG6944, D5, Dm, Dm(0), Dm0, Dm1, Dm2, DmelCG6944, DmLamin, Dmo, DmO, Dm[[0]], Dm[[1]], Dm[[2]], Dm[[mit]], Dm[[o]], DM[[O]], jf27, l(2)04643, l(2)25Ec, l(2)gdh-7, l(2)gdh7, l(2)jf27, lam, Lam Dm[[0]], Lam(Dm0), lamDm0, LamDm[[0], lamDm[[0]], LamDm[[0]], lamin, lamin Dm0, lamin Dm[[0]], Lamin Dm[[0]], Lam[[Dm0]], misg, nlam, cb948, fk66d12, wu:fk66d12, lmna-A, MGC127505, LMNA, fpl, idc, lfp, cddc, emd2, fpld, hgps, ldp1, lmn1, lmnc, pro1, cdcd1, cmd1a, cmt2b1, lgmd1b, Lamin-A

Application Details

Application Notes: Western blotting: At 2u/ml with the appropriate system to detect Lamin A/C in cells and tissues. Immunohistochemistry (Paraffin-embedded Sections): At 1-2u/ml to detect Lamin A/C in formalin fixed and paraffin embedded tissues. Boiling the sections is required. Other applications have not been tested. Optimal dilutions should be determined by end user.

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Research Area: Cytoskeleton, Extracellular Matrix

Restrictions: For Research Use only