Annexin A1 (ANXA1) antibody

Antigen: Annexin A1 (ANXA1)

Synonyms: ANX1, LPC1, Lpc1, Anx-1, Lpc-1, Anx-A1, C430014K04Rik, p35, Anx1, ANXA1, anx1a, anxa1, wu:fa01d11, wu:fa05d11, wu:fk69h01, MGC64363, anx1, lpc1, MGC76270, MGC89164, ANNEXIN, ANNEXIN A1, ANNEXIN ARABIDOPSIS 1, ATOXY5, F14D7.2, F14D7_2, OXY5, DKFZp468O0210

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343499

Additional Information

Alternative name: Annexin I

Immunogen: A synthetic peptide corresponding to a sequence near the C-terminal of human Annexin I, different from the related rat and mouse sequence by two amino acids Purity

Format: Affinity-purified

Isotype: IgG  (Matching secondary antibodies)

Description: Annexin I, also known as lipocortin I (Lipo1), belongs to the family of annexins. These proteins are thought to control the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes. In two lipocortins (I and II) a short amino-terminal sequence distinct from the core structure has potential regulatory functions which are dependent on its phosphorylation state. The gene in the mouse encodes a protein of 346 amino acid residues. Mouse Lipo1 gene spans about 17 kb and is divided into 13 exons. Annexin I gene, mapped to 9q11-q22, is located on mouse chromosome 19. Annexin I acts through the formyl peptide receptor on human neutrophils. Peptides derived from the unique N-terminal domain of annexin I serve as FPR ligands and trigger different signaling pathways in a dose-dependent manner.

Specificity: Human, mouse, rat. No cross reactivity with other proteins.

Synonyms: ANX1, LPC1, Lpc1, Anx-1, Lpc-1, Anx-A1, C430014K04Rik, p35, Anx1, ANXA1, anx1a, anxa1, wu:fa01d11, wu:fa05d11, wu:fk69h01, MGC64363, anx1, lpc1, MGC76270, MGC89164, ANNEXIN, ANNEXIN A1, ANNEXIN ARABIDOPSIS 1, ATOXY5, F14D7.2, F14D7_2, OXY5, DKFZp468O0210

Application Details

Application Notes: Western blotting: At 1-2u/ml with the appropriate system to detect Annexin I in cells and tissues. Immunohistochemistry (Paraffin-embedded Sections): At 1-2u/ml to detect Annexin I in formalin fixed and paraffin embedded tissues. Digesting the sections is required. Immunocytochemistry Suitable Other applications have not been tested. Optimal dilutions should be determined by end user.

Purity: Immunogen affinity purified.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

Research Area: Coagulation

Restrictions: For Research Use only