Amyloid beta (Abeta) antibody

Antigen: Amyloid beta (Abeta)

Synonyms: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma, APP

Clonality: Monoclonal (AP-5)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343510

Additional Information

Alternative name: betalpha-Amyloid Protein

Immunogen: Synthetic ß-amyloid peptide (1-40), conjugated to KLH. Purification Purified by the goat anti-mouse IgG affinity chromatography.

Format: Affinity-purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: AP-5

Description: Beta amyloid protein is 4.2-kD polypeptide. Glenner and Wong (1984) purified a protein derived from the twisted beta-pleated sheet fibrils present in cerebrovascular amyloidoses and in the amyloid plaques associated with Alzheimer disease. The proteins from both disorders have an identical 28-amino acid sequence. memory deficits in middle-aged Tg2576 mice are caused by the extracellular accumulation of a 56-kDa soluble amyloid-beta assembly. Amyloid beta protein (Abeta) deposition in the brain is a hallmark of Alzheimer's disease (AD).

Specificity: Human. No cross reactivity with other proteins.

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Sections): At 0.5-1µg/ml to detect amyloid protein in formalin fixed and paraffin embedded tissues. Other applications have not been tested. Optimal dilutions should be determined by end user.

Buffer: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.2mg NaN3 as preservative.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100µg/ml.

Restrictions: For Research Use only