Tryptophan Hydroxylase 1 (TPH1) antibody

Antigen: Tryptophan Hydroxylase 1 (TPH1)

Synonyms: tph, tph1, tphD1, SERGEF, TPH1, TPH2, TPRH, TRPH, MGC119994, Tph, TPH, LOC100229598

Clonality: Monoclonal (Try-63)

Host: Mouse

Reactivity: Human, Rat (Rattus), Rabbit

Application: Western Blotting (WB)

Catalog no.: ABIN343520

Additional Information

Alternative name: Tryptophan Hydroxylase

Immunogen: Recombinant rabbit tryptophan hydroxylase. Purification Purified by the goat anti-mouse IgG affinity chromatography.

Format: Affinity-purified

Isotype: IgG3  (Matching secondary antibodies)

Clone: Try-63

Description: Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). Tryptophan hydroxylase\atalyzes the biopterin-dependent monooxygenation of tryptophan to5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Human tryptophan hydroxylase (TPH) is mapped to chromosome 11p15.3-p14 by in situ hybridization.

Specificity: Human, rat, rabbit. No cross reactivity with other proteins.

Application Details

Application Notes: Western blotting: At0.5-1µg/ml with the appropriate system to detect tryptophan hydroxylase in cells and tissues. Other applications have not been tested. Optimal dilutions should be determined by end user.

Buffer: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.2mg NaN3 as preservative.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100µg/ml.

Research Area: Cancer, Amino Acids, Metabolism, Enzymes

Restrictions: For Research Use only