Desmin (DES) antibody

Antigen: Desmin (DES)

Synonyms: DES, des-a, MGC52614, des-b, MGC80853, CSM1, CSM2, CMD1I, FLJ12025, FLJ39719, FLJ41013, FLJ41793, des, csm1, csm2, desm, cmd1i, MGC75911, LOC395906, LOC100220724, desmin, cb290, fb59a12, MGC109859, wu:fb59a12, zgc:109859, MGC154009, wu:fc11d08

Clonality: Monoclonal (DES-82)

Host: Please enquire

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN343581

Additional Information

Alternative name: Desmin

Immunogen: Desmin from pig stomach. Purification Purified by the goat anti-mouse IgG affinity chromatography.

Format: Affinity-purified

Isotype: IgG1

Clone: DES-82

Description: Desmin belongs to the type III family of intermediate filaments, a class of cytoskeletal elements. DES gene encodes desmin, a muscle-specific cytoskeletal protein found in smooth, cardiac, and heart muscles. Tidball (1992) found that desmin was codistributed with actin thin filaments within the cellular processes of myotendinous junctions in frog skeletal muscle. DES gene contains 9 exons and spans about 8.4 kb. By in situ hybridization, Viegas-Pequignot et al. (1989) localized the gene to 2q35. Desmin mutation responsible for idiopathic dilated cardiomyopathy.

Specificity: Human, mouse, rat. No cross reactivity with other proteins.

Synonyms: DES, des-a, MGC52614, des-b, MGC80853, CSM1, CSM2, CMD1I, FLJ12025, FLJ39719, FLJ41013, FLJ41793, des, csm1, csm2, desm, cmd1i, MGC75911, LOC395906, LOC100220724, desmin, cb290, fb59a12, MGC109859, wu:fb59a12, zgc:109859, MGC154009, wu:fc11d08

Application Details

Application Notes: Western blotting: At 2 µg/ml with the appropriate system to detect desmin in cells and tissues. Immunohistochemistry (Paraffin-embedded Sections): At 2-4 µg/ml to detect desmin in formalin fixed and paraffin embedded tissues. Other applications have not been tested. Optimal dilutions should be determined by end user.

Buffer: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.2mg NaN3 as preservative.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100µg/ml.

Research Area: Cancer, Cytoskeleton

Restrictions: For Research Use only