Junction Plakoglobin (JUP) antibody

Antigen: Junction Plakoglobin (JUP)

Synonyms: DP3, PDGB, PKGB, CTNNG, DPIII, ARVD12, dp3, pdgb, pkgb, ctnng, dpiii, MGC75867, MGC137835, plak

Clonality: Monoclonal (CN-3)

Host: Please enquire

Reactivity: Human, Rat (Rattus), Chicken

Application: Western Blotting (WB)

Catalog no.: ABIN343605

Additional Information

Alternative name: Catenin Gamma (Plakoglobin)

Immunogen: Recombinant chicken plakoglobin. Purification Purified by the goat anti-mouse IgG affinity chromatography.

Format: Affinity-purified

Isotype: IgG1

Clone: CN-3

Description: Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.

Specificity: Human, rat, chicken. No cross reactivity with other proteins.

Application Details

Application Notes: Western blotting: At 2 µg/ml with the appropriate system to detect catenin ? (plakoglobin) in cells and tissues. Immunohistochemistry(F) At 4 µg/ml to detect catenin ? (plakoglobin) in formalin/acetone fixed tissues. Immunocytochemistry Suitable Other applications have not been tested. Optimal dilutions should be determined by end user.

Buffer: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.2mg NaN3 as preservative.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100µg/ml.

Research Area: Signaling

Restrictions: For Research Use only