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Otoferlin antibody (OTOF)

Details for Product anti-OTOF Antibody No. ABIN346890, Supplier: Login to see New
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Antigen
Reactivity
Human
(12), (3), (2)
Host
Mouse
(10), (3)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
(8), (7), (6), (5), (3), (1), (1)
Pubmed 2 references available
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Quantity 100 μL
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Immunogen GST-fusion protein (fragment 1-395)
Clone 13A9
Isotype IgG1
Fragment Chain kappa
Specificity Reacts with human 220 kDa Otoferlin protein.
Cross-Reactivity (Details) Reacts with human 220 kDa Otoferlin protein.
Purification Purified (protein A)
Alternative Name Otoferlin (OTOF Antibody Abstract)
Background Otoferlin is a key presynaptic SNARE protein involved in the control of neurotranmitter release and in the fusion of synaptic vesicle with the neuonal plasma membrane. Expressed in the synapses of cochlear inner hair cells
UniProt Q9HC10
Application Notes Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC 1:100 - 1:500 IP 1:50 - 1:200 WB 1:200 - 1:1000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Concentration 1 mg/mL
Buffer Tris 0,1M, glycine 0,1M, sucrose 2 %
Storage -20 °C,4 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
Supplier Images
Image no. 1 for anti-Otoferlin antibody (OTOF) (ABIN346890) anti-Otoferlin (OTOF) antibody
Product cited in: Rouillon, Marcolla, Roux et al.: "Results of cochlear implantation in two children with mutations in the OTOF gene." in: International journal of pediatric otorhinolaryngology, Vol. 70, Issue 4, pp. 689-96, 2006 (PubMed).

Background publications Roux, Safieddine, Nouvian et al.: "Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse." in: Cell, Vol. 127, Issue 2, pp. 277-89, 2006 (PubMed).

Catalog No. ABIN346890

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