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SMN1 antibody (Survival Motor Neuron 1)

Details for Product anti-SMN1 Antibody No. ABIN346903, Supplier: Log in to see
  • AI849087
  • BCD541
  • C-BCD541
  • Gemin1
  • GEMIN1
  • SMN
  • Smn
  • SMN1
  • SMNC
  • TDRD16B
Clonality (Clone)
Monoclonal ()
Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
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Immunogen GST-SMN fusion protein
Clone SCB3
Isotype IgG1 kappa
Specificity Reacts with human 38-40 kDa SMN protein in the various human foetal tissues.
Purification Purified (protein A)
Alternative Name Survival Motor Neuron Protein (SMN1 Antibody Abstract)
Background The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs.
Gene ID 6606
UniProt Q16637
Application Notes

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
-IHC : 1/500 to 1/2 000 -IP : 1/50 to 1/200 -WB : 1/500 to 1/2 000 -ELISA: 1/1 000 to 1/5 000

Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Concentration 1 mg/mL
Buffer PBS
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
Background publications Burlet, Huber, Bertrandy, Ludosky, Zwaenepoel, Clermont, Roume, Delezoide, Cartaud, Munnich, Lefebvre: "The distribution of SMN protein complex in human fetal tissues and its alteration in spinal muscular atrophy." in: Human molecular genetics, Vol. 7, Issue 12, pp. 1927-33, 1998 (PubMed).

Lefebvre, Bürglen, Reboullet, Clermont, Burlet, Viollet, Benichou, Cruaud, Millasseau, Zeviani: "Identification and characterization of a spinal muscular atrophy-determining gene." in: Cell, Vol. 80, Issue 1, pp. 155-65, 1995 (PubMed).