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DPYSL3 antibody (Dihydropyrimidinase-Like 3) (C-Term)

Details for Product anti-DPYSL3 Antibody No. ABIN347042, Supplier: Log in to see
Antigen
  • CRMP-4
  • Crmp4
  • crmp4
  • CRMP4
  • CRMP4A
  • CRMP4B
  • DPYSL3
  • dpysl3
  • dpysl3-b
  • DRP-3
  • drp-3
  • DRP-3-B
  • drp3
  • DRP3
  • LCRMP
  • lcrmp
  • MGC69487
  • nsp1
  • tuc-4
  • TUC-4b
  • tuc4
  • TUC4
  • ulip
  • ULIP
  • Ulip
  • ulip-1
  • ULIP-1
  • Ulip1
  • xCRMP4
Epitope
C-Term
20
15
9
3
2
2
2
1
1
1
1
1
Reactivity
Human
83
34
32
2
2
1
1
1
1
Host
Rabbit
70
15
Clonality
Polyclonal
Conjugate
This DPYSL3 antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
72
45
35
11
11
7
6
6
4
1
1
Supplier
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Immunogen A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator
Isotype IgG
Specificity Reacts with 65 kDa CRMP-4 from human rat and mouse. Do not react with CRMP-1, CRMP-2, CRMP-3 or CRMP-5.
Purification Antiserum
Alternative Name Collapsin Response Mediator Protein 4 (CRMP-4) (DPYSL3 Antibody Abstract)
Background Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration

Dihydropyrimidinase-related protein 3 (DRP-3) Unc-33-like phosphoprotein 1 (ULIP-1) Gene name: DPYSL3, CRMP4, DRP3, ULIP, ULIP1
UniProt Q14195
Application Notes Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
-IHC : 1/500 - WB :1/2 000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Storage 4 °C/-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
Supplier Images
 image for anti-DPYSL3 antibody (Dihydropyrimidinase-Like 3) (C-Term) (ABIN347042) anti-Dihydropyrimidinase-Like 3 (DPYSL3) (C-Term) antibody
 image for anti-DPYSL3 antibody (Dihydropyrimidinase-Like 3) (C-Term) (ABIN347042) anti-Dihydropyrimidinase-Like 3 (DPYSL3) (C-Term) antibody (Image 2)
Product cited in: Blasco, Bernard-Marissal, Vourch, Guettard, Sunyach, Augereau, Khederchah, Mouzat, Antar, Gordon, Veyrat-Durebex, Besson, Andersen, Salachas, Meininger, Camu, Pettmann, Andres, Corcia: "A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS." in: Human mutation, Vol. 34, Issue 7, pp. 953-60, 2013 (PubMed).

Bretin, Reibel, Charrier, Maus-Moatti, Auvergnon, Thevenoux, Glowinski, Rogemond, Prémont, Honnorat, Gauchy: "Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain." in: The Journal of comparative neurology, Vol. 486, Issue 1, pp. 1-17, 2005 (PubMed).

Ricard, Rogemond, Charrier, Aguera, Bagnard, Belin, Thomasset, Honnorat: "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 18, pp. 7203-14, 2001 (PubMed).

Honnorat, Byk, Kusters, Aguera, Ricard, Rogemond, Quach, Aunis, Sobel, Mattei, Kolattukudy, Belin, Antoine: "Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes." in: The European journal of neuroscience, Vol. 11, Issue 12, pp. 4226-32, 2000 (PubMed).

Balin, Loewy, Appelt: "Analysis of transglutaminase-catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease." in: Methods in enzymology, Vol. 309, pp. 172-86, 1999 (PubMed).

Background publications Duplan, Bernard, Casseron, Dudley, Thouvenot, Honnorat, Rogemond, De Bovis, Aebischer, Marin, Raoul, Henderson, Pettmann: "Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 2, pp. 785-96, 2010 (PubMed).

Veyrac, Giannetti, Charrier, Reymond-Marron, Aguera, Rogemond, Honnorat, Jourdan: "Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system." in: The European journal of neuroscience, Vol. 21, Issue 10, pp. 2635-48, 2005 (PubMed).

Quach, Duchemin, Rogemond, Aguera, Honnorat, Belin, Kolattukudy: "Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons." in: Molecular and cellular neurosciences, Vol. 25, Issue 3, pp. 433-43, 2004 (PubMed).

Charrier, Reibel, Rogemond, Aguera, Thomasset, Honnorat: "Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders." in: Molecular neurobiology, Vol. 28, Issue 1, pp. 51-64, 2003 (PubMed).