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Dihydropyrimidinase-Like 3 (DPYSL3) (C-Term) antibody

Details for Product No. ABIN347042, Supplier: Login to see
Antigen
Epitope
C-Term
1
Reactivity
Human
1
Host
Rabbit
1
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
1
1
1
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Immunogen A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator
Isotype IgG
Specificity Reacts with 65 kDa CRMP-4 from human rat and mouse. Do not react with CRMP-1, CRMP-2, CRMP-3 or CRMP-5.
Cross-Reactivity (Details) Reacts with 65 kDa CRMP-4 from human rat and mouse. Do not react with CRMP-1, CRMP-2, CRMP-3 or CRMP-5.
Purification Purified (protein A)
Background Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration
Pathways
Application Notes Optimal dilution should be determined by the end user.
The following are guidelines only :
-IHC : 1/500 - WB :1/2 000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Concentration 1 mg/mL
Buffer Tris 0,1M, glycine 0,1M, sucrose 2 %
Storage -20 °C,4 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
Supplier Images
 image for anti-Dihydropyrimidinase-Like 3 (DPYSL3) (C-Term) antibody (ABIN347042) anti-Dihydropyrimidinase-Like 3 (DPYSL3) (C-Term) antibody
 image for anti-Dihydropyrimidinase-Like 3 (DPYSL3) (C-Term) antibody (ABIN347042) anti-Dihydropyrimidinase-Like 3 (DPYSL3) (C-Term) antibody (Image 2)
Product cited in: Blasco, Bernard-Marissal, Vourch et al.: "A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS." in: Human mutation, Vol. 34, Issue 7, pp. 953-60, 2013 (PubMed).

Bretin, Reibel, Charrier et al.: "Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain." in: The Journal of comparative neurology, Vol. 486, Issue 1, pp. 1-17, 2005 (PubMed).

Ricard, Rogemond, Charrier et al.: "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 18, pp. 7203-14, 2001 (PubMed).

Honnorat, Byk, Kusters et al.: "Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes." in: The European journal of neuroscience, Vol. 11, Issue 12, pp. 4226-32, 2000 (PubMed).

Balin, Loewy, Appelt: "Analysis of transglutaminase-catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease." in: Methods in enzymology, Vol. 309, pp. 172-86, 1999 (PubMed).

Background publications Duplan, Bernard, Casseron et al.: "Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 2, pp. 785-96, 2010 (PubMed).

Veyrac, Giannetti, Charrier et al.: "Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system." in: The European journal of neuroscience, Vol. 21, Issue 10, pp. 2635-48, 2005 (PubMed).

Quach, Duchemin, Rogemond et al.: "Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons." in: Molecular and cellular neurosciences, Vol. 25, Issue 3, pp. 433-43, 2004 (PubMed).

Charrier, Reibel, Rogemond et al.: "Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders." in: Molecular neurobiology, Vol. 28, Issue 1, pp. 51-64, 2003 (PubMed).