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Details for Product No. ABIN347117

Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody

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Antigen
Synonyms Nyw1, 2310079H06Rik, A130023A14, AA474864, AV021921, D030051N19Rik, mKIAA1736, DCAF3, WDR94
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN347117
Quantity 100 µL
Price
423.98 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 5 to 6 Business Days
Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Isotype IgG
Specificity Antiserum reacts specifically with 120 kDa of mouse protein.
Cross-Reactivity Rat (Rattus), Human
Cross-Reactivity (Details) Reacts with mouse 120 kDa Ambra1 protein. Cross reacts with human and rat protein.
Purification Antiserum
Alternative Name Activating molecule in Beclin 1-regulated autophagy (Ambra-1)
UniProt Q9C0C7
Application Notes Optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Concentration 1 mg/mL
Buffer Tris 0,1 M, glycine 0,1 M, sucrose 2 %
Storage 4 °C/-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20 °C. Store reconstituted antibodies at +4 °C. For extended periods store in aliquots at -20 °C. Antibodies are guaranteed for 6 month from date of receipt.
Product cited in: Di Bartolomeo, Corazzari, Nazio et al.: "The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 155-68, 2010 (PubMed).

Armstrong, Corazzari, Martin et al.: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, 2011 (PubMed).

Van Humbeeck, Cornelissen, Hofkens et al.: "Parkin interacts with ambra1 to induce mitophagy." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 28, pp. 10249-61, 2011 (PubMed).

Fimia, Stoykova, Romagnoli et al.: "Ambra1 regulates autophagy and development of the nervous system." in: Nature, Vol. 447, Issue 7148, pp. 1121-5, 2007 (PubMed).

Alternatives for antigen "Autophagy/beclin-1 Regulator 1 (AMBRA1)", type "Antibodies"
Hosts (58)
Reactivities (50), (44), (30), (14), (12), (2)
Applications (48), (30), (23), (17), (10), (6), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (9), (3), (2), (1)
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