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Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody

Details for Product No. ABIN347118, Supplier: Log in to see
Antigen
Epitope
N-Term
20
18
13
5
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
76
44
35
1
1
Host
Rabbit
78
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
57
35
26
17
12
5
4
4
3
1
1
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Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Isotype IgG
Specificity Reacts with mouse 120 kDa Ambra1 protein. Cross reacts with human and rat protein.
Purification Purified (protein A)
Background Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation
Gene ID 55626
UniProt Q9C0C7
Application Notes

Working dilution: Optimal dilution should be determined by the end user.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Concentration 1 mg/mL
Buffer Tris 0,1M, glycine 0,1M, sucrose 2 %
Storage 4 °C,-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
Supplier Images
 image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody
 image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 2)
 image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 3)
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 image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 5)
 image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 6)
 image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 7)
Product cited in: Armstrong, Corazzari, Martin et al.: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, 2011 (PubMed).

Di Bartolomeo, Corazzari, Nazio et al.: "The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 155-68, 2010 (PubMed).

Background publications Fimia, Stoykova, Romagnoli et al.: "Ambra1 regulates autophagy and development of the nervous system." in: Nature, Vol. 447, Issue 7148, pp. 1121-5, 2007 (PubMed).