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AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term)

Details for Product anti-AMBRA1 Antibody No. ABIN347118, Supplier: Log in to see
Antigen
  • 2310079H06Rik
  • A130023A14
  • AA474864
  • AV021921
  • D030051N19Rik
  • DCAF3
  • mKIAA1736
  • Nyw1
  • WDR94
Epitope
N-Term
23
18
14
5
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
97
64
52
3
3
Host
Rabbit
99
Clonality
Polyclonal
Conjugate
This AMBRA1 antibody is un-conjugated
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
76
51
42
34
19
15
13
4
4
4
1
Supplier
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Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Isotype IgG
Specificity Reacts with mouse 120 kDa Ambra1 protein. Cross reacts with human and rat protein.
Purification Antiserum
Alternative Name Activating Molecule in BECN1-Regulated Autophagy Protein 1 (Ambra1) (AMBRA1 Antibody Abstract)
Background Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation

Activating molecule in BECN1-regulated autophagy protein 1 autophagy/beclin 1 regulator 1 Gene name: Ambra1, Kiaa1736
Gene ID 55626
UniProt Q9C0C7
Application Notes Working dilution: Optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Storage 4 °C/-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
Supplier Images
 image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody
 image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 2)
 image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 3)
 image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 4)
 image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 5)
 image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 6)
 image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN347118) anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (Image 7)
Product cited in: Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, 2011 (PubMed).

Di Bartolomeo, Corazzari, Nazio, Oliverio, Lisi, Antonioli, Pagliarini, Matteoni, Fuoco, Giunta, DAmelio, Nardacci, Romagnoli, Piacentini, Cecconi, Fimia: "The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 155-68, 2010 (PubMed).

Background publications Fimia, Stoykova, Romagnoli, Giunta, Di Bartolomeo, Nardacci, Corazzari, Fuoco, Ucar, Schwartz, Gruss, Piacentini, Chowdhury, Cecconi: "Ambra1 regulates autophagy and development of the nervous system." in: Nature, Vol. 447, Issue 7148, pp. 1121-5, 2007 (PubMed).