Trace Amine Associated Receptor 5 (TAAR5) (C-Term) antibody

Antigen: Trace Amine Associated Receptor 5 (TAAR5)

Synonyms: PNR, MGC138414, MGC138416, RP11-295F4.5, Gm227, TAAR5

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN349970

Additional Information

Alternative name: trace amine-associated receptor 5 (TAAR5)

UniProt: O14804

Immunogen: A synthetic peptide as a part of human & monkey TAAR5 conjugated to immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Orphan receptor. Ligands are likely small molecules, either sharing some similarities withtrace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra. Also known as:trace amine-associated receptor 5,trace amine associated receptor 5, Putative neurotransmitter receptor, TAAR5.

Specificity: Appears to be specific for TAAR5.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Zeng, Fan, Rand et al.: "Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain." in: Biochemical and biophysical research communications, Vol. 242, Issue 3, pp. 575-8, 1998 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Lindemann, Ebeling, Kratochwil et al.: "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." in: Genomics, Vol. 85, Issue 3, pp. 372-85, 2005 (PubMed).