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Details for Product No. ABIN349972

ATG3 Autophagy Related 3 Homolog (S. Cerevisiae) (ATG3) antibody

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Antigen
Synonyms APG3, APG3-LIKE, APG3L, PC3-96, Apg3l, Atg3l, 2610016C12Rik, Pig1, PIG-1, ATATG3, K11J9.1, K11J9_1, atg3, im:6910145, wu:fb15g12, zgc:64156
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN349972
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from human autophagy-related protein 3 (ATG3, APG3, APG3L, APG3-like, hApg3, protein PC3-96) conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for ATG3.
Purity IgG
Alternative Name autophagy-related protein 3 (ATG3, APG3, APG3L, APG3-like)
Background Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential forautophagy.
Function: GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential forautophagy.
Subcellular location: Cytoplasm
Tissue specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. Also known as: ATG3, APG3, APG3L, APG3-like, hApg3, protein PC3-96, FLJ22125, MGC15201, DKFZp564M1178.
UniProt Q9NT62
Research Area Autophagy
Application Notes IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Tanida, Tanida-Miyake, Komatsu et al.: "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13739-44, 2002 (PubMed).

Brill, Salomon, Ficarro et al.: "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." in: Analytical chemistry, Vol. 76, Issue 10, pp. 2763-72, 2004 (PubMed).

Alternatives for antigen "ATG3 Autophagy Related 3 Homolog (S. Cerevisiae) (ATG3)", type "Antibodies"
Hosts (60), (17), (3)
Reactivities (80), (40), (40), (25), (25), (24), (24), (1), (1), (1)
Applications (55), (28), (20), (16), (12), (10), (9), (4), (3), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (7), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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