Beclin 1, Autophagy Related (BECN1) (AA 400-450) antibody

Details for Product No. ABIN349984
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Antigen
Synonyms beclin-1, atg6, vps30, beclin1, Beclin-1, becn1, zgc:73097, ATG6, VPS30, 4921513J16Rik, 5430417M23Rik, Atg6
Epitope
AA 400-450
(25), (14), (9), (7), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(213), (85), (58), (31), (30), (21), (18), (15), (12), (6), (1), (1), (1)
Host
Rabbit
(164), (55), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (9), (9), (9), (8), (8), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(187), (85), (68), (56), (40), (31), (17), (17), (16), (10), (5), (1)
Pubmed 6 references available
Quantity 100 μL
Options
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Catalog No. ABIN349984
454.67 $
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Immunogen A synthetic peptide from aa region 400-450 of human Beclin-1 conjugated to blue carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.
Specificity Specific for Beclin-1.
Purification Whole serum
Alternative Name Beclin 1
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role inautophagy.
Subcellular location: Cytoplasm. Golgi apparatus membrane, Peripheral membrane protein. Note: Expressed in dendrites and cell bodies of cerebellar Purkinje cells
Tissue specificity: Ubiquitous Also known as: Beclin-1, BECN1, GT197, ATG6, VPS30, beclin1.
Research Area Cancer, Transcription Factors, Autophagy
Application Notes Use at a dilution of 1 : 300 to 1 : 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
anti-Beclin 1, Autophagy Related (BECN1) (AA 400-450) antibody IF (confocal) on rat brain at 1 : 500 dilution using Rabbit antibody to human, rat, mouse coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, GT197, ATG6, VPS30): whole serum (ABIN349984), DAPI counterstained.
anti-Beclin 1, Autophagy Related (BECN1) (AA 400-450) antibody (2) IF (confocal) on rat brain at 1 : 500 dilution using Rabbit antibody to human, rat, mouse coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, GT197, ATG6, VPS30): whole serum (ABIN349984), DAPI counterstained appearing in blue.
anti-Beclin 1, Autophagy Related (BECN1) (AA 400-450) antibody (3) IF (confocal) on rat brain at 1 : 500 dilution using Rabbit antibody to human, rat, mouse coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, GT197, ATG6, VPS30): whole serum (ABIN349984), DAPI counterstained appearing in blue.
General Rommens, Durocher, McArthur et al.: "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21." in: Genomics, Vol. 28, Issue 3, pp. 530-42, 1996 (PubMed).

Aita, Liang, Murty et al.: "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21." in: Genomics, Vol. 59, Issue 1, pp. 59-65, 1999 (PubMed).

Liang, Jackson, Seaman et al.: "Induction of autophagy and inhibition of tumorigenesis by beclin 1." in: Nature, Vol. 402, Issue 6762, pp. 672-6, 2000 (PubMed).

Kihara, Kabeya, Ohsumi et al.: "Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network." in: EMBO reports, Vol. 2, Issue 4, pp. 330-5, 2001 (PubMed).

Koneri, Goi, Hirono et al.: "Beclin 1 gene inhibits tumor growth in colon cancer cell lines." in: Anticancer research, Vol. 27, Issue 3B, pp. 1453-7, 2007 (PubMed).

Lee, Jeong, Yoo et al.: "Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 115, Issue 12, pp. 1357-63, 2008 (PubMed).

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